202277-52-9

Usage

InChI:InChI=1/C14H15BrN2O3/c1-3-20-13(18)11-8(2)16-14(19)17-12(11)9-5-4-6-10(15)7-9/h4-7,12H,3H2,1-2H3,(H2,16,17,19)

Upstream product

• 3132-99-8 m-bromobenzoic aldehyde 
• 141-97-9 ethyl acetoacetate 
• 57-13-6 urea 
• 15852-73-0 (3-Bromophenyl)methanol 
• 75148-49-1 3-bromobenzaldehyde diethylacetal 
• 4433-85-6 2-ethyl-3-oxobutanoic acid 

Downstream Products

• 1159493-12-5 C₁₂H₁₃BrN₄O₂ 
• 1092074-28-6 ethyl 4-(3-bromophenyl)-1,2-dihydro-6-methyl-2-oxopyrimidine-5-carboxylate 

Relevant academic research and scientific papers

Fe3O4@mesoporous SBA-15: A robust and magnetically recoverable catalyst for one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones via the Biginelli reaction

A magnetic nanoparticle conjugated mesoporous nanocatalyst (Fe 3O4@mesoporous SBA-15) with a high surface area has been synthesized by chemical conjugation of magnetite (Fe3O4) nanoparticles with functionalized

Applications of lanthanide trichloride hydrates, prepared from mischmetall, in the Biginelli reaction

An inexpensive alloy of light lanthanides, called mischmetall, has been used in the preparation of a mixture of lanthanide trichloride hydrates. The use of this new type of material is described in Biginelli reactions. Georg Thieme Verlag Stuttgart.

Magnetic Silica-Coated Picolylamine Copper Complex [Fe3O4@SiO2@GP/Picolylamine-Cu(II)]-Catalyzed Biginelli Annulation Reaction

An efficient and heterogeneous novel magnetic silica-coated picolylaminecopper complex [Fe3O4@SiO2@GP/Picolylamine-Cu(II)] was synthesized, characterized, and employed as a magnetically recoverable nanocatalyst in Biginelli condensation for the preparatio

Aiding the versatility of simple ammonium ionic liquids by the synthesis of bioactive 1,2,3,4-tetrahydropyrimidine, 2-aminothiazole and quinazolinone derivatives

Simple ammonium ionic liquids [ILs] are efficient, green, environmentally friendly catalysts in promoting the Biginelli condensation reaction, Hantzsch reaction and Niementowski reaction to afford 1,2,3,4-tetrahydropyrimidine, 2-aminothiazole and quinazolinone derivatives respectively by eliminating the need for harmful volatile organic solvents. These [ILs] are air and water stable, easy to prepare and cost-effective. The effects of the anions and cations present in [IL] on reactions were investigated. The results clearly indicated that the Biginelli condensation reaction, Hantzsch reaction and Niementowski reaction were heavily influenced by the acidity of [IL], and among various ammonium ionic liquids, [Et3NH][HSO4] showed the best catalytic activity. Furthermore, [IL] could be easily separated and reused with a slight loss of its activity. This technique provided a good alternative way for the industrial synthesis of 1,2,3,4-tetrahydropyrimidinones, 2-aminothiazoles and quinazolinones. The present processes are eco-friendly methods for the synthesis of these derivatives authenticated by several green parameters, namely,E-factor, process mass intensity, reaction mass efficiency, atom economy, and carbon efficiency.

Tungsten-substituted molybdophosphoric acid impregnated with kaolin: effective catalysts for the synthesis of 3,4-dihydropyrimidin-2(1: H)-ones v i a biginelli reaction

A series of highly reusable heterogeneous catalysts (10-25 wt% PMo7W5/kaolin), consisting of tungsten-substituted molybdophosphoric acid, H3PMo7W5O40·24H2O (PMo7W5) impregnated with acid treated kaolin clay was synthesized by the wetness impregnation meth

Natural dolomitic limestone-catalyzed synthesis of benzimidazoles, dihydropyrimidinones, and highly substituted pyridines under ultrasound irradiation

Natural dolomitic limestone (NDL) is employed as a heterogeneous green catalyst for the synthesis of medicinally valuable benzimidazoles, dihydropyrimidinones, and highly functionalized pyridines via C–N, C–C, and C–S bond formations in a mixture of ethan

1, 1'-sulfinyldiethylammonium bis (hydrogen sulfate) as a recyclable dicationic ionic liquid catalyst for the efficient solvent-free synthesis of 3, 4-dihydropyrimidin-2(1H)-ones Via biginelli reaction

Objective: A facile and efficient method for synthesis of 3, 4-dihydropyrimidin-2(1H)-ones via Biginelli reaction catalyzed by a novel dicationic Br?nsted acidic ionic liquid, [(EtNH2)2SO][HSO4]2, has been succe

Synthesis, cytotoxic assessment, and molecular docking studies of 2,6-diaryl-substituted pyridine and 3,4-dihydropyrimidine-2(1H)-one scaffolds

Cancer is one of the main global health problems. In order to develop novel antitumor agents, we synthesized 3,4-dihydropyrimidine-2(1H)-one (DHPM) and 2,6-diaryl-substituted pyridine derivatives as potential antitumor structures and evaluated their cytot

An efficient and recyclable L-proline triflate ionic liquid catalyst for one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones via the multi-component Biginelli reaction

A simple, efficient, and environmentally-friendly process has been developed for the synthesis of L-proline triflate ionic liquid (L-ProTfO) from L-proline and triflic acid using ultrasound irradiation. The combination of L-proline triflate ionic liquid t

Introduction of a novel dicationic Br?nsted acidic ionic liquid based on pyrazine and its application in the synthesis of xanthenediones and 3, 4-dihydropyrimidin-2(1H)-ones under solvent-free conditions

A novel dicationic Br?nsted acidic ionic liquid based on pyrazine has been prepared and characterized by FTIR, 1H NMR, 13C NMR, MS, thermal gravimetric and differential thermal gravimetric analysis and also Hammett acidity function.