20245-72-1

Basic information

• Product Name: 2-PHENYL-2-PYRROLIDIN-1-YL-ETHANOL
• Synonyms: 2-PHENYL-2-PYRROLIDIN-1-YL-ETHANOL;β-Phenyl-1-pyrrolidineethanol
• CAS NO: 20245-72-1
• Molecular Formula: C₁₂H₁₇NO
• Molecular Weight: 191.27
• Product Categories: Aromatics;Metabolites & Impurities
• Mol File: 20245-72-1.mol
• Article Data: 20

Chemical Properties

• Boiling Point: 299.2°C at 760 mmHg
• Flash Point: 137.5°C
• Appearance: /
• Density: 1.106g/cm³
• Vapor Pressure: 0.00054mmHg at 25°C
• Refractive Index: 1.577
• PKA: 14.45±0.10(Predicted)
• CAS DataBase Reference: 2-PHENYL-2-PYRROLIDIN-1-YL-ETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PHENYL-2-PYRROLIDIN-1-YL-ETHANOL(20245-72-1)
• EPA Substance Registry System: 2-PHENYL-2-PYRROLIDIN-1-YL-ETHANOL(20245-72-1)

Safety Data

• Hazardous Substances Data: 20245-72-1(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 20245-72-1 differently. You can refer to the following data:
1. A metabolite of Amixetrine
2. A metabolite of Amixetrine (N-(2-phenyl-2-isoamyloxy)ethylpyrrolidine-HCl).

InChI:InChI=1/C12H17NO/c14-10-12(13-8-4-5-9-13)11-6-2-1-3-7-11/h1-3,6-7,12,14H,4-5,8-10H2

Upstream product

• 123-75-1 pyrrolidine 
• 41252-83-9 2-bromo-2-phenylethanol 
• 58907-93-0 3-phenyl-hexahydro-pyrrolo[2,1-b]oxazole 
• 40435-14-1 (S)-1-phenyl-2-(tosyloxy)ethanol 
• 100-42-5 styrene 
• 96-09-3 styrene oxide 
• 22083-21-2 ethyl 2-phenyl-2-(pyrrolidin-1-yl)acetate 

Downstream Products

• 18358-63-9 methyl 4-(N-methyl)aminobenzoate 
• 58907-93-0 3-phenyl-hexahydro-pyrrolo[2,1-b]oxazole 
• 108836-99-3 acetic acid-(β-pyrrolidino-phenethyl ester) 

Relevant articles and documents

Light-enhanced acid catalysis over a metal-organic framework

A Br?nsted acid-functionalized metal-organic framework (MOF), MIL-101-SO3H, was prepared for acid-engaged esterification reactions. Strikingly, for the first time, the MOF exhibits significantly light-enhanced activity and possesses excellent activity and recyclability, with even higher activity than H2SO4 under light irradiation.

Green Regio- and Enantioselective Aminolysis Catalyzed by Graphite and Graphene Oxide under Solvent-Free Conditions

The ring-opening reactions of epoxides with amines were efficiently and regioselectively catalyzed by high-surface-area graphite and graphene oxide under metal-free and solvent-free conditions. For epoxides without aryl groups, catalytic activity was observed only for graphene oxide, and hence, the activity must have been due to its acidic groups. For styrene oxide, instead, graphite and graphene oxide exhibited rather similar catalytic activities, and hence, the activity was mainly due to activation of the electrophilic epoxide by π-stacking interactions with the graphitic π system. The described aminolysis procedure is green and cheap because the catalyst can be recovered and recycled without loss of efficiency. Moreover, these heterogeneous catalysts exert high stereoselective control in the presence of nonracemic epoxides and provide chiral β-amino alcohols with enantiomeric excess values up to 99 %.

Quaternary ammoniums and a cationic sodium complex as supramolecular catalysts in ring-opening of epoxides by amines

Supramolecular ionic organocatalysts and a metal-based catalyst were investigated in the ring-opening of epoxides by amines, without any artifice to enhance conversion (i.e., solvophobic effect, extended reaction time, heating, excess of amine, high catalyst loading). Different β-amino-alcohols were obtained in satisfying conversion (50-80%) in 24 h, under mild conditions.