20279-38-3

Usage

Uses

Used in Pharmaceutical Industry:
Succinic Acid Monoisopropyl Ester is used as an intermediate in the synthesis of prodrugs for the treatment or prevention of central nervous system (CNS) diseases. One such application is in the preparation of prodrugs of ketamine, a dissociative anesthetic and analgesic drug. The esterification of ketamine with Succinic Acid Monoisopropyl Ester enhances its solubility, bioavailability, and pharmacokinetic properties, allowing for more effective treatment of CNS disorders.

Upstream product

• 3859-41-4 1,3-cyclopentadione 
• 67-63-0 isopropyl alcohol 
• 765-69-5 2-Methylcyclopentane-1,3-dione 

Downstream Products

• 924-88-9 diisopropyl succinate 
• 1267369-02-7 isopropyl 4-(3,4-difluorophenyl)-4-oxobutanoate 
• 75150-82-2 3-{N'-[5-(2-Chloro-4-trifluoromethyl-phenoxy)-2-nitro-phenyl]-N,N'-dimethyl-hydrazinocarbonyl}-propionic acid isopropyl ester 
• 75132-51-3 3-{N'-Ethyl-N'-[2-nitro-5-(2,4,6-trichloro-phenoxy)-phenyl]-hydrazinocarbonyl}-propionic acid isopropyl ester 
• 75132-43-3 3-{N'-[5-(2,4-Dichloro-6-fluoro-phenoxy)-2-nitro-phenyl]-N'-ethyl-hydrazinocarbonyl}-propionic acid isopropyl ester 
• 75131-78-1 3-{N'-[5-(2-Chloro-4-trifluoromethyl-phenoxy)-2-nitro-phenyl]-N'-methyl-hydrazinocarbonyl}-propionic acid isopropyl ester 
• 75131-40-7 3-{N'-[5-(2-Chloro-4-trifluoromethyl-phenoxy)-2-nitro-phenyl]-hydrazinocarbonyl}-propionic acid isopropyl ester 
• 75132-50-2 3-{N'-Methyl-N'-[2-nitro-5-(2,4,6-trichloro-phenoxy)-phenyl]-hydrazinocarbonyl}-propionic acid isopropyl ester 
• 75132-48-8 3-{N'-[2-Nitro-5-(2,4,6-trichloro-phenoxy)-phenyl]-N'-propyl-hydrazinocarbonyl}-propionic acid isopropyl ester 
• 75132-39-7 3-{N'-[5-(2,4-Dichloro-6-fluoro-phenoxy)-2-nitro-phenyl]-N'-propyl-hydrazinocarbonyl}-propionic acid isopropyl ester 

Relevant academic research and scientific papers

Direct oxidative cleavage of α- and β-dicarbonyls and α-hydroxyketones to diesters with KHSO5

Presented is a methodology to oxidatively cleave α-hydroxyketones and α- or β-diones using the environmentally benign reagent KHSO 5, prepared easily from Oxone, to diesters in one simple transformation. In addition, we undertook a mechanistic study to provide a plausible mechanistic interpretation. These reactions may prove to be valuable alternatives to other related metal-mediated processes.