202811-09-4Relevant articles and documents
Compounds with growth hormone releasing properties
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Example 10, (2010/01/31)
There are disclosed novel synthetic peptides of the general formula (I) Compounds of formula (I) stimulate the release of growth hormone from the pituitary in humans and animals. A method for increasing the rate and extent of growth of animals to increase their milk and wool production or for the treatment of ailments, and the use of the compounds of formula (I) for the preparation of medicaments, are also disclosed.
New highly potent dipeptidic growth hormone secretagogues with low molecular weight
Peschke, Bernd,Ankersen, Michael,Hansen, Thomas Kruse,Hansen, Birgit Sehested,Lau, Jesper,Nielsen, Karin Kramer,Raun, Kirsten
, p. 599 - 618 (2007/10/03)
Based on NN703, low molecular weight growth hormone secretagouges (GHSs) with a reduced number of hydrogen binding sites were designed by removal of the C-terminal amide group. The compounds were highly potent in combination with high efficacy in a rat pituitary cell assay, being characterized with EC50 values down to 0.8 nM. Selected compounds were tested in in vivo animal models. The oral bioavailability in dogs was 16-44%. Also, the ED50 values of the compounds were determined both in dog and swine. (C) 2000 Editions scientifiques et medicales Elsevier SAS.
Compounds with growth hormone releasing properties
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, (2008/06/13)
Novel peptide derivatives, compositions containing them, and their use for treating medical disorders resulting from a deficiency in growth hormone are disclosed. The peptides have the formula (I): STR1 wherein a, b, A, R1, L1, D, R3, R4, R2, L2, E and G are as defined in the specification. These peptides exhibit improved resistance to proteolytic degradation, and hence, improved bioavailability.