20284-78-0

Basic information

• Product Name: Galegine sulfate
• Synonyms: Galegine sulfate;Galegine HeMisulfates
• CAS NO: 20284-78-0
• Molecular Formula: 2C₆H₁₃N₃*H₂O₄S
• Molecular Weight: 225.266
• Mol File: 20284-78-0.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 220.2 °C at 760 mmHg
• Flash Point: 87 °C
• Appearance: /
• Vapor Pressure: 0.114mmHg at 25°C
• CAS DataBase Reference: Galegine sulfate(CAS DataBase Reference)
• NIST Chemistry Reference: Galegine sulfate(20284-78-0)
• EPA Substance Registry System: Galegine sulfate(20284-78-0)

Safety Data

• Hazardous Substances Data: 20284-78-0(Hazardous Substances Data)

Usage

General Description

Galegine sulfate is a chemical compound derived from the plant Galega officinalis, also known as goat's rue. It is a natural source of guanidine, a compound that has been shown to lower blood sugar levels. Galegine sulfate has been researched for its potential use in managing diabetes, as it can mimic the effects of insulin by stimulating glucose uptake in cells and inhibiting glucose production in the liver. However, it should be used cautiously as excessive levels of guanidine can be toxic and harmful to the body. Further research is needed to determine its safety and efficacy for use as a treatment for diabetes.

InChI:InChI=1/C6H13N3.H2O4S/c1-5(2)3-4-9-6(7)8;1-5(2,3)4/h3H,4H2,1-2H3,(H4,7,8,9);(H2,1,2,3,4)

Upstream product

• 13822-06-5 3,3-dimethylallylamine 
• 867-44-7 S-Methylisothiourea sulfate 

Downstream Products

• 352-97-6 guanidineacetic acid 
• 67-64-1 acetone 

Relevant articles and documents

Benzylguanidines and other galegine analogues inducing weight loss in mice

Dimethylallylguanidine, also known as galegine, isolated from Galega officinalis, has been shown to have weight reducing properties in vivo. Substitution of the guanidine group with an N-cyano group and replacement of guanidine with amidine, pyrimidine, pyridine, or the imidazole moieties removed the weight reducing properties when evaluated in BALB/c mice. However, retention of the guanidine and replacement of the dimethylallyl group by a series of functionalized benzyl substituents was shown to exhibit, and in some cases significantly improve, the weight reducing properties of these molecules in BALB/c, ob/ob, and diet induced obesity (DIO) mice models. The lead compound identified, across all models, was 1-(4-chlorobenzyl)guanidine hemisulfate, which gave an average daily weight difference (% from time-matched controls; ± SEM) of -19.7 ± 1.0, -11.0 ± 0.7, and -7.3 ± 0.8 in BALB/c, ob/ob, and DIO models, respectively.