202982-69-2

Basic information

• Product Name: 4-CHLORO-2-FLUORO-5-IODOTOLUENE
• Synonyms: 4-CHLORO-2-FLUORO-5-IODOTOLUENE;1-Chloro-5-fluoro-2-iodo-4-Methylbenzene
• CAS NO: 202982-69-2
• Molecular Formula: C₇H₅ClFI
• Molecular Weight: 270.47
• Mol File: 202982-69-2.mol

Chemical Properties

• Boiling Point: 243.1°Cat760mmHg
• Flash Point: 100.9°C
• Appearance: /
• Density: 1.879g/cm³
• Vapor Pressure: 0.0509mmHg at 25°C
• Refractive Index: 1.594
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-CHLORO-2-FLUORO-5-IODOTOLUENE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-2-FLUORO-5-IODOTOLUENE(202982-69-2)
• EPA Substance Registry System: 4-CHLORO-2-FLUORO-5-IODOTOLUENE(202982-69-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• Hazardous Substances Data: 202982-69-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-CHLORO-2-FLUORO-5-IODOTOLUENE is used as a chemical intermediate for the synthesis of various pharmaceuticals. Its unique halogenated structure allows for the development of new drugs with specific therapeutic properties, contributing to the advancement of medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, 4-CHLORO-2-FLUORO-5-IODOTOLUENE serves as a key intermediate in the production of agrochemicals. Its incorporation into these compounds can enhance their effectiveness in pest control and crop protection, thereby supporting agricultural productivity.
Used in Dye and Pigment Production:
4-CHLORO-2-FLUORO-5-IODOTOLUENE is utilized as a building block in the creation of organic dyes and pigments. Its distinctive molecular structure imparts color and stability to these products, which are essential in various applications such as textiles, plastics, and printing inks.
Given the potential hazards associated with 4-CHLORO-2-FLUORO-5-IODOTOLUENE due to its halogenated nature, it is imperative that strict safety measures are adhered to during its production, use, and disposal to ensure the protection of both human health and the environment.

InChI:InChI=1/C7H5ClFI/c1-4-2-7(10)5(8)3-6(4)9/h2-3H,1H3

Upstream product

• 452-75-5 4-chloro-2-fluorotoluene 

Downstream Products

• 333447-71-5 1,2-dideoxy-1-(2-chloro-4-fluoro-5-methylphenyl)-β-D-ribofuranose 

Relevant articles and documents

Remarkable sensitivity to DNA base shape in the DNA polymerase active site

(Figure Presented) Shaping up: DNA polymerase I can distinguish easily and with high sensitivity between nucleobases that have the same size but differ in shape. The shape, altered through variation in the position of the halogen substituent(s), plays mor

Synthesis of 1-(2-deoxy-β-D-ribofuranosyl)-2,4-difluoro-5- substituted-benzene thymidine mimics, some related α-anomers, and their evaluation as antiviral and anticancer agents

A group of unnatural 1-(2-deoxy-β-D-ribofuranosyl)-2.4-difluorobenzenes having a variety of C-5 substituents (H, Me, F, Cl, Br, I, CF3, CN, NO2, NH2), designed as thymidine mimics, were synthesized for evaluation as anticancer and antiviral agents. The coupling reaction of 3,5-bis-O-(p-chlorobenzoyl) 2-deoxy-α-D-ribofuranosyl chloride with an organocadmium reagent [(2,4-difluorophenyl)2Cd] afforded a mixture of the α- and β-anomeric products (α:β = 3:1 to 10:1 ratio). Treatment of the α-anomer with BF3·Et2O in nitroethane at 110-120°C for 30 min was developed as an efficient method for epimerization of the major α-anomer to the desired β-anomer. The 5-substituted (H, Me, Cl, I, NH2) β-anomers exhibited negligible cytotoxicity in a MTT assay (CC50 = 10-3-10-4 M range), relative to thymidine (CC50 = 10-3-10-5 M range), against a variety of cancer cell lines. In contrast, the 5-NO2 derivative was more cytotoxic (CC50 = 10-5-10-6 M range). A number of 5-substituted β-anomers, and some related α-anomers, that were evaluated using a wide variety of antiviral assay systems [HSV-1, HSV-2, varicella-zoster virus (VZV), vaccinia virus, vesicular stomatitis, cytomegalovirus (CMV) and human immunodeficiency (HIV-1, HIV-2) viruses], showed that this class of unnatural C-aryl nucleoside mimics are inactive antiviral agents.