2031-23-4

Basic information

• Product Name: 1-(3-Chloropropyl)-4-methylpiperazine dihydrochloride
• Synonyms: Piperazine, 1-(3-chloropropyl)-4-methyl-, hydrochloride (1:2);1-(3-Chloropropyl)-4-methylpiperazine dihydrochloride ,98%;1-Methyl-4-(3-chloropropyl)piperazine dihydrochloride;1-(3-Chloropropyl)-4-methylpiperazine DiHCl;1-(3-CHLOROPROPYL)-4-METHYL PIPERAZINE DIHYDROCHLORIDE;1-(3-CHLOROPROPYL)-4-METHYLPIPERAZINE HCL;1-(3-CHLORO-PROPYL)-4-METHYL-PIPERAZINE, HYDROCHLORIDE;N-(3-Chloropropyl)-N'-methylpiperazine2hydrochloride
• CAS NO: 2031-23-4
• Molecular Formula: C₈H₁₇ClN₂*2ClH
• Molecular Weight: 249.61
• EINECS: 217-981-8
• Mol File: 2031-23-4.mol
• Article Data: 4

Chemical Properties

• Melting Point: 255-257 °C (decomp)(Solv: ethanol (64-17-5))
• Boiling Point: 242.9 °C at 760 mmHg
• Flash Point: 100.7 °C
• Appearance: /
• Vapor Pressure: 0.033mmHg at 25°C
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: DMSO, Methanol
• CAS DataBase Reference: 1-(3-Chloropropyl)-4-methylpiperazine dihydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-Chloropropyl)-4-methylpiperazine dihydrochloride(2031-23-4)
• EPA Substance Registry System: 1-(3-Chloropropyl)-4-methylpiperazine dihydrochloride(2031-23-4)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 2031-23-4(Hazardous Substances Data)

Usage

Uses

1-(3-Chloropropyl)-4-methylpiperazine Dihydrochloride

InChI:InChI=1/C8H17ClN2.2ClH/c1-10-5-7-11(8-6-10)4-2-3-9;;/h2-8H2,1H3;2*1H

Upstream product

• 109-01-3 1-methyl-piperazine 
• 5317-33-9 3-(4-methyl-1-piperazinyl)-1-propanol 
• 109-70-6 1.3-chlorobromopropane 
• 82980-50-5 3-(4-methyl-piperazino)-propan-1-ol; dihydrochloride 

Downstream Products

• 280580-86-1 4-Anilino-5-bromo-2-{4-[3-(4-methylpiperazin-1-yl)propoxy]anilino}pyrimidine 
• 676545-20-3 1-{5-methoxy-4-[3-(4-methyl-piperazin-1-yl)-propoxy]-2-nitro-phenyl}-ethanone 
• 676545-18-9 5-methoxy-4-[3-(4-methyl-1-piperazinyl)propoxy]-2-nitrobenzaldehyde 
• 676545-21-4 2-amino-5-methoxy-4-[3-(4-methyl-1-piperazinyl)propoxy]benzaldehyde 
• 704870-86-0 1-{3-methoxy-4-[3-(4-methyl-piperazin-1-yl)-propoxy]-phenyl}-ethanone 
• 687635-75-2 3-methoxy-4-[3-(4-methyl-1-piperazinyl)propoxy]benzaldehyde 
• 20686-45-7 2-propionyl-10-[3-(4-methylpiperazino)propyl]-phenothiazine 
• 1053-74-3 2-acetil-10-<3'-(4''-metilpiperazin-1''-il)>propilfenotiazina 
• 58-38-8 prochlorperazine 

Relevant articles and documents

Manganese-Catalyzed Anti-Markovnikov Hydroamination of Allyl Alcohols via Hydrogen-Borrowing Catalysis

Controlling the selectivity in a hydroamination reaction is an extremely challenging yet highly desirable task for the diversification of amines. In this article, a selective formal anti-Markovnikov hydroamination of allyl alcohols is presented. It enables the versatile synthesis of valuable γ-amino alcohol building blocks. A phosphine-free Earth's abundant manganese(I) complex catalyzed the reaction under hydrogen-borrowing conditions. A vast range of aliphatic, aromatic amines, drug molecules, and natural product derivatives underwent successful hydroamination with primary and secondary allylic alcohols with excellent functional group tolerance (57 examples). The catalysis could be performed on a gram scale and has been applied for the synthesis of drug molecules. The mechanistic studies revealed the metal-ligand bifunctionality as well as hemilability of the ligand backbone as the key design principle for the success of this catalysis.

3-(INDOLYL)- OR 3-(AZAINDOLYL)-4-ARYLMALEIMIDE COMPOUNDS AND THEIR USE IN TUMOR TREATMENT

The present invention relates to a compound of formula (I) wherein R, R and R are as defined in the description and the physiologically acceptable salts thereof as well as the physiologically acceptable solvates of the compounds of formula I and of the salts thereof. The compounds of formula I are suitable for treating tumors