203115-75-7

Upstream product

• 83-38-5 2,6-dichlorobenzaldehyde 
• 203115-71-3 (1R,3S)-1,3-Bis-(2,6-dichloro-phenyl)-propane-1,3-diol 
• 203115-70-2 1,3-bis(2,6-dichlorophenyl)-3-hydroxy-1-propanone 
• 2040-05-3 2,6 dichloroacetophenone 
• 203115-73-5 Methanesulfonic acid (1R,3S)-1,3-bis-(2,6-dichloro-phenyl)-3-methanesulfonyloxy-propyl ester 

Relevant academic research and scientific papers

1,3-Diphenylpropane-1,3-diamines XI [1]. Conversion of a 3-hydroxy-1,3-diphenylpropan-1-one to 1,3-diphenylpropane-1,3-diamines

Highly diastereoselective BH3/THF syn-reduction of the 3-hydroxy-1,3-diphenylpropan-1-one/BBr3 complex 3/BBr3 (cf. Sarko) afforded the meso-diol 4, whereas racemate 5 was obtained by BH3/THF reduction without complexation. Mesylation, exchange of mesylate by azide, and reduction with SnCl2/thiophenol led to the diamines 10 and 11 which were also produced by reductive N-N cleavage of the 4,5-dihydropyrazole 13.