2040-05-3

Basic information

• Product Name: 2',6'-Dichloroacetophenone
• Synonyms: 1-(2,6-Dichlorophenyl)ethanone;Ethanone, 1-(2,6-dichlorophenyl)-;RARECHEM AH CK 0081;2',6'-DICHLOROACETOPHENONE;2,6-DICHLOROACETOPHENONE;1-(2,6-dichlorophenyl)ethan-1-one;2',6'-Dichloroacetophenone 98%
• CAS NO: 2040-05-3
• Molecular Formula: C₈H₆Cl₂O
• Molecular Weight: 189.04
• EINECS: 218-035-7
• Product Categories: Aromatic Acetophenones & Derivatives (substituted);C7 to C8;Carbonyl Compounds;Ketones
• Mol File: 2040-05-3.mol
• Article Data: 4

Chemical Properties

• Melting Point: 37-41 °C(lit.)
• Boiling Point: 176-180°C 83mm
• Flash Point: >230 °F
• Appearance: Colorless/Low Melting Solid
• Density: 1.304 g/cm³
• Vapor Pressure: 0.219mmHg at 25°C
• Refractive Index: 1.548
• Storage Temp.: Sealed in dry,Room Temperature
• Water Solubility: Insoluble in water.
• BRN: 2440104
• CAS DataBase Reference: 2',6'-Dichloroacetophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 2',6'-Dichloroacetophenone(2040-05-3)
• EPA Substance Registry System: 2',6'-Dichloroacetophenone(2040-05-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 2040-05-3(Hazardous Substances Data)

Usage

Uses

2',6'-Dichloroacetophenone is is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.

InChI:InChI=1/C8H6Cl2O/c1-5(11)8-6(9)3-2-4-7(8)10/h2-4H,1H3

Upstream product

• 53066-19-6 1-(2',6'-dichlorophenyl)-ethanol 
• 1194-65-6 2,6-dichloro-benzonitrile 
• 74-88-4 methyl iodide 
• 541-73-1 1,3-Dichlorobenzene 
• 4659-45-4 2,6-Dichlorobenzoyl chloride 
• 20082-66-0 trimethyl(2,6-dichlorophenyl)silicium 
• 75-36-5 acetyl chloride 
• 917-64-6 methyl magnesium iodide 
• 83-38-5 2,6-dichlorobenzaldehyde 

Downstream Products

• 81547-71-9 2,6-dichlorophenacyl chloride 
• 78710-01-7 2,6-dichlorophenacylidene chloride 
• 81547-77-5 2,6-dichlorophenacylidene bromide 
• 81547-72-0 2-bromo-1-(2,6-dichloro-phenyl)ethanone 
• 203115-79-1 (E)-1,3-Bis-(2,6-dichloro-phenyl)-propenone 
• 203115-70-2 1,3-bis(2,6-dichlorophenyl)-3-hydroxy-1-propanone 
• 64-19-7 acetic acid 
• 541-73-1 1,3-Dichlorobenzene 
• 1006879-68-0 (E)-1-(2,6-dichlorophenyl)-3-(4-nitrophenyl)propenone 
• 68373-14-8 sulbactum 
• 524685-51-6 1-(2,6-dichlorophenyl)-3-(3-nitrophenyl)-1,3-propanedione 
• 1186033-50-0 C₁₀H₁₁ClOS 
• 1552267-41-0 N-[4-(2,6-dichlorophenyl)-1,3-thiazol-2-yl]-2-[4-(ethylsulfonyl)phenyl]acetamide 
• 736901-08-9 4-(2,6-dichlorphenyl)-1,3-thiazol-2-amine 

Relevant articles and documents

Base-free oxidation of alcohols enabled by nickel(ii)-catalyzed transfer dehydrogenation

An efficient nickel(ii)-catalyzed transfer dehydrogenation oxidation of alcohols is reported that relies on cyclohexanone as the formal oxidant and does not require the use of an external base. The synthetic utility of this protocol is demonstratedviathe facile oxidation of structurally complicated natural products.

Process for the manufacture of ketones

Ketones are prepared by reacting carboxylic acid halides, in particular carboxylic acid chlorides, with aluminum-alkyl compounds, optionally in the presence of an aluminum trihalide, in methylene chloride as the solvent, at a temperature between about 20° and about 100° C., preferably between about 30° and about 60° C., more preferably of about 40° C. which is the reflux temperature of the methylene chloride. When operating at a temperature above approximately 40° C., pressure higher than atmospheric is applied. The reaction mixture is worked up in usual manner, suitably by decomposition with water followed by distillation.