203115-79-1Relevant academic research and scientific papers
1,3-Diphenylpropane-1,3-diamines XI [1]. Conversion of a 3-hydroxy-1,3-diphenylpropan-1-one to 1,3-diphenylpropane-1,3-diamines
Kaiser,Bielmeier,Wiegrebe
, p. 1247 - 1254 (1997)
Highly diastereoselective BH3/THF syn-reduction of the 3-hydroxy-1,3-diphenylpropan-1-one/BBr3 complex 3/BBr3 (cf. Sarko) afforded the meso-diol 4, whereas racemate 5 was obtained by BH3/THF reduction without complexation. Mesylation, exchange of mesylate by azide, and reduction with SnCl2/thiophenol led to the diamines 10 and 11 which were also produced by reductive N-N cleavage of the 4,5-dihydropyrazole 13.
Synthesis and biological evaluation of aromatic enones related to curcumin
Robinson, Thomas Philip,Hubbard IV, Richard B.,Ehlers, Tedman J.,Arbiser, Jack L.,Goldsmith, David J.,Bowen, J. Phillip
, p. 4007 - 4013 (2007/10/03)
Curcumin, a natural product isolated from the spice turmeric, has been shown to exhibit a wide range of pharmacological activities including certain anti-cancer properties. It has been specifically shown to be an effective inhibitor of angiogenesis both in vitro and in vivo. Using curcumin as a lead compound for anti-angiogenic analog design, a series of structurally related compounds utilizing a substituted chalcone backbone have been synthesized and tested via an established SVR cell proliferation assay. The results have yielded a wide range of compounds that equal or exceed curcumin's ability to inhibit endothelial cell growth in vitro. Due to both their commercial availability and their fairly straightforward synthetic preparation, these low molecular weight compounds are attractive leads for developing future angiogenic inhibitors.
