203180-24-9

Upstream product

• 5876-51-7 5-iodo-1,3-benzodioxole 
• 124-63-0 methanesulfonyl chloride 
• 203180-23-8 (R)-1-[4-(Benzo[1,3]dioxole-5-sulfonyl)-phenyl]-ethanol 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 442868-87-3 1-[4-(benzo[1,3]dioxole-5-sulfonyl)-phenyl]-ethanone 
• 203180-21-6 1-[4-(benzo[1,3]dioxol-5-ylsulfanyl)-phenyl]-ethanone 

Downstream Products

• 442868-88-4 (R)-4-{(S)-1-[4-(Benzo[1,3]dioxole-5-sulfonyl)-phenyl]-ethyl}-3-methyl-piperazine-1-carboxylic acid tert-butyl ester 
• 203180-27-2 (R)-1-{(S)-1-[4-(Benzo[1,3]dioxole-5-sulfonyl)-phenyl]-ethyl}-2-methyl-piperazine 
• 203180-28-3 4-((R)-4-{(S)-1-[4-(Benzo[1,3]dioxole-5-sulfonyl)-phenyl]-ethyl}-3-methyl-piperazin-1-yl)-piperidine-1-carboxylic acid tert-butyl ester 
• 203180-30-7 (R)-1-{(S)-1-[4-(Benzo[1,3]dioxole-5-sulfonyl)-phenyl]-ethyl}-2-methyl-4-piperidin-4-yl-piperazine 

Relevant academic research and scientific papers

Piperazine derivatives useful as CCR5 antagonists

The use of CCR5 antagonists of the formula or a pharmaceutically acceptable salt thereof, wherein R is optionally substituted phenyl, pyridyl, thiophenyl or naphthyl; R1is hydrogen or alkyl; R2is substituted phenyl, substituted heter

Substituted 2-(R)-Methyl piperazines as muscarinic M2 selective ligands

A novel series of 2-(R)-methyl-substituted piperazines (e.g., 2) is described. They are potent M2 selective ligands that have > 100-fold selectivity versus the M1 receptor. In the rat microdialysis assay, compound 14 showed significantly enchanced levels of acetylcholine after oral administration.