203180-28-3

Upstream product

• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 203180-27-2 (R)-1-{(S)-1-[4-(Benzo[1,3]dioxole-5-sulfonyl)-phenyl]-ethyl}-2-methyl-piperazine 
• 441772-07-2 (R)-1-[(S)-1-(4-Bromo-phenyl)-ethyl]-6-methyl-piperazine-2,5-dione 
• 441772-08-3 (R)-1-[(S)-1-(4-Bromo-phenyl)-ethyl]-2-methyl-piperazine 
• 182141-70-4 N-[(1S)-1-(4-bromophenyl)ethyl]-2,2,2-trifluoroacetamide 
• 27298-97-1 (S)-1-(4-bromophenyl)ethylamine 
• 2354-91-8 (S)-2,2,2-trifluoro-(α-methylbenzyl)acetamide 
• 442868-88-4 (R)-4-{(S)-1-[4-(Benzo[1,3]dioxole-5-sulfonyl)-phenyl]-ethyl}-3-methyl-piperazine-1-carboxylic acid tert-butyl ester 
• 203180-24-9 Methanesulfonic acid (R)-1-[4-(benzo[1,3]dioxole-5-sulfonyl)-phenyl]-ethyl ester 
• 442868-87-3 1-[4-(benzo[1,3]dioxole-5-sulfonyl)-phenyl]-ethanone 
• 203180-21-6 1-[4-(benzo[1,3]dioxol-5-ylsulfanyl)-phenyl]-ethanone 
• 163765-44-4 (R)-tert-butyl 3-methylpiperazine-1-carboxylate 
• 5876-51-7 5-iodo-1,3-benzodioxole 
• 403-42-9 1-(4-fluorophenyl)ethanone 

Downstream Products

• 203180-30-7 (R)-1-{(S)-1-[4-(Benzo[1,3]dioxole-5-sulfonyl)-phenyl]-ethyl}-2-methyl-4-piperidin-4-yl-piperazine 

Relevant academic research and scientific papers

Synthesis and structure-Activity relationships of M2-Selective muscarinic receptor ligands in the 1-[4-(4-Arylsulfonyl)-phenylmethyl]-4-(4-piperidinyl)-piperazine family

The synthesis and muscarinic binding properties of compounds based on the 1-[4-(4-arylsulfonyl)phenylmethyl]-4-(1-aroyl-4-piperidinyl)-piperazine skeleton are described. For compounds, substituted with appropriately configured methyl groups at the benzylic center and at the piperazine 2-position, high levels of selective, M2 subtype affinity could be obtained, particularly when the terminal N-aroyl residue was ortho-substituted.

Substituted 2-(R)-Methyl piperazines as muscarinic M2 selective ligands

A novel series of 2-(R)-methyl-substituted piperazines (e.g., 2) is described. They are potent M2 selective ligands that have > 100-fold selectivity versus the M1 receptor. In the rat microdialysis assay, compound 14 showed significantly enchanced levels of acetylcholine after oral administration.