203186-02-1Relevant articles and documents
PIPERIDINE DERIVATIVES USEFUL AS CCR5 ANTAGONISTS
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Page/Page column 30, (2010/02/12)
Pharmaceutical compositions for the treatment of HIV are provided comprising compounds of formula (II) or a pharmaceutically acceptable salt or isomer thereof, in combination with specified antiviral agents.
Synthesis, SAR, and biological evaluation of oximino-piperidino-piperidine amides. 1. Orally bioavailable CCR5 receptor antagonists with potent anti-HIV activity
Palani, Anandan,Shapiro, Sherry,Josien, Hubert,Bara, Thomas,Clader, John W.,Greenlee, William J.,Cox, Kathleen,Strizki, Julie M.,Baroudy, Bahige M.
, p. 3143 - 3160 (2007/10/03)
We previously reported the discovery of 4-[(Z)-(4-bromophenyl)(ethoxyimino)methyl]-1′-[(2,4-dimethyl-3 -pyridinyl)carbonyl]-4′-methyl-1,4′-bipipefidine N-oxide 1 (SCH 351125) as an orally bioavailable human CCR5 antagonist for the treatment of HIV-1 infec