203312-35-0Relevant academic research and scientific papers
Diastereocontrolled synthesis of pyrrolidines by nickel promoted tandem cyclization-quenching of aminobromodienes
Cancho, Yolanda,Martin, Joan M.,Martinez, Maria,Llebaria, Amadeu,Moreto, Josep M.,Delgado, Antonio
, p. 1221 - 1232 (2007/10/03)
The nickel promoted tandem cyclization-quenching of tethered aminobromodienes has been extended to the synthesis of 2,3,4-trisubstituted pyrrolidines. By a judicious choice of substituents on the starting aminohalodiene, the diastereoselectivity of the process can be efficiently controlled. When a chiral auxiliary on the nitrogen atom is used, enantiomerically enriched pyrrolidines can be obtained after removal of the auxiliary.
