203312-38-3

Usage

Molecular structure

A complex organic compound with a spiro ring structure.

Hydroxy group

A polar, hydrophilic functional group (-OH) that can form hydrogen bonds.

Methoxy group

A functional group (-OCH3) that imparts some polarity and aromatic character.

4-Azaspiro ring

A nitrogen-containing spiro ring (azaspiro) that adds to the compound's complexity and potential pharmacological activity.

Dimethylphenyl group

Aromatic group with two methyl substituents (-CH3) that may contribute to the compound's aromatic properties.

Aromatic properties

The presence of the dimethylphenyl group suggests that the compound may exhibit aromatic characteristics.

Pharmacological or biological activity

The specific structure and functional groups of the compound indicate potential for pharmacological or biological activity, making it of interest for further study in medicinal chemistry or drug development.

Upstream product

• 753441-74-6 methyl cis-1-amino-4-methoxycyclohexane-1-carboxylate 
• 387825-55-0 cis-1-amino-4-methoxycyclohexane-1-carboxylic acid 
• 387825-48-1 cis-8-methoxy-1,3-diazaspiro[4.5]decane-2,4-dione 
• 13482-23-0 4-methoxycyclohexanone 
• 203313-47-7 methyl cis-1-[2-(2,5-dimethylphenyl)acetamido]-4-methoxycyclohexane-1-carboxylate 

Downstream Products

• 203313-25-1 spirotetramat 

Relevant academic research and scientific papers

A High-Yield and Cost-Effective Synthesis of Spirotetramat

Abstract: cis-8-Methoxy-1,3-diazaspiro[4.5]decane-2,4-dione, the key intermediate in the synthesis of spirotetramat, was synthesized by catalytic hydrogenation, oxidation, and Bucherer–Bergs reaction with 4-methoxycyclohexan-1-one as raw material. Spirotetramat was obtained in an overall yield of 20.4% by a multi-step reaction sequence including hydrolysis, esterification, acylation, intramolecular condensation, and O-acylation. The advantages of the proposed method are mild conditions, simple operation, and good to excellent yields in each step.

Support vector machine (SVM) classification model based rational design of novel tetronic acid derivatives as potent insecticidal and acaricidal agents

A novel support vector machine (SVM) classification model was established for distinguishing potent and weak/inactive insecticides. Classification model-based rational design of novel tetronic acid derivatives was then performed to choose the preferable site of spirotetramat for chemical modification. Afterwards, eleven C5′-oxime ether-derived spirotetramat analogues, which are indicated as "potent class", were synthesized and validated by biological assays, revealing that theoretical estimates are significantly consistent with experimental activities of these compounds. To be of interest, the most promising compound 91b exhibited excellent insecticidal and acaricidal activities. Moreover, molecular docking was further implemented to propose the possible interaction mode of acetyl-CoA carboxylase (ACCase) and compounds 91b, 91j, and 91k, providing some important and useful guidelines for further development.