203389-54-2Relevant academic research and scientific papers
A simple strategy for the preparation of 4-aminoquinolines from β-functionalized enamines
Palacios, Francisco,Aparicio, Domitila,Garcia, Jesus
, p. 1647 - 1656 (1998)
An easy and efficient synthesis of 4-aminoquinolines substituted with a phosphine oxide group in the 3-position 1, is described. The key step is a heterocyclization of cyano-aryl β-enamino phosphine oxides 4. The treatment of β-enamines derived from phosphonium salts 7, with a base afforded phosphazenes 8 and the hydrolysis of these phosphazenes led to the formation of substituted 4-aminoquinolines 9.
