Tetrahedron p. 1647 - 1656 (1998)
Update date:2022-08-02
Topics:
Palacios, Francisco
Aparicio, Domitila
Garcia, Jesus
An easy and efficient synthesis of 4-aminoquinolines substituted with a phosphine oxide group in the 3-position 1, is described. The key step is a heterocyclization of cyano-aryl β-enamino phosphine oxides 4. The treatment of β-enamines derived from phosphonium salts 7, with a base afforded phosphazenes 8 and the hydrolysis of these phosphazenes led to the formation of substituted 4-aminoquinolines 9.
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Doi:10.1016/S0277-5387(00)00446-0
(2000)Doi:10.1021/jacs.0c04670
(2020)Doi:10.1016/S0040-4039(97)10856-5
(1998)Doi:10.1021/jo026238i
(2002)Doi:10.1038/nature25749
(2018)Doi:10.1080/00397919808006846
(1998)
