2034-61-9

Basic information

• Product Name: 2-hydroxy-1-(4-hydroxy-3-methoxyphenyl)propan-1-one
• Synonyms: 2-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)-propan-1-one;1-Propanone, 2-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-
• CAS NO: 2034-61-9
• Molecular Formula: C₁₀H₁₂O₄
• Molecular Weight: 196.1999
• Mol File: 2034-61-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 369.6°C at 760 mmHg
• Flash Point: 147.9°C
• Density: 1.243g/cm³
• Vapor Pressure: 4.1E-06mmHg at 25°C
• Refractive Index: 1.559
• CAS DataBase Reference: 2-hydroxy-1-(4-hydroxy-3-methoxyphenyl)propan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-hydroxy-1-(4-hydroxy-3-methoxyphenyl)propan-1-one(2034-61-9)
• EPA Substance Registry System: 2-hydroxy-1-(4-hydroxy-3-methoxyphenyl)propan-1-one(2034-61-9)

Safety Data

• Hazardous Substances Data: 2034-61-9(Hazardous Substances Data)

Upstream product

• 1835-14-9 1-(4'-hydroxy-3'-methoxyphenyl)propan-1-one 
• 2503-46-0 1-(4-hydroxy-3-methoxyphenyl)2-propanone 
• 10144-63-5 1-(3-methoxy-4-acetoxyphenyl)-2-propanone 
• 97-54-1 2-methoxy-4-propenylphenol 
• 93044-49-6 1-acetoxy-1-(4-acetoxy-3-methoxy-phenyl)-acetone 
• 116145-41-6 1-bromo-1-(3-methoxy,4-acetophenyl)propanone 

Downstream Products

• 121-34-6 3-methoxy-4-hydroxybenzoic acid 
• 144-62-7 oxalic acid 
• 121-33-5 vanillin 

Relevant articles and documents

Discovery of the 2,4′-Dihydroxy-3′-methoxypropiophenone Biosynthesis Genes in Aspergillus oryzae

The filamentous fungus Aspergillus oryzae has 27 putative iterative type I polyketide synthase (PKS) gene clusters, but the secondary metabolites produced by them are mostly unknown. Here, we focused on eight clusters that were reported to be expressed at relatively high levels in a transcriptome analysis. By comparing metabolites between an octuple-deletion mutant of these eight PKS gene clusters and its parent strain, we found that A. oryzae produced 2,4′-dihydroxy-3′-methoxypropiophenone (1) and its precursor, 4′-hydroxy-3′-methoxypropiophenone (3) in a specific liquid medium. Furthermore, an iterative type I PKS (PpsB) encoded by AO090102000166 and an acetyl-CoA ligase (PpsA) encoded downstream from ppsB were shown to be essential for their biosynthesis. PpsC, encoded upstream from ppsB, was shown to have 3-binding activity (Kd=26.0±6.2 μM) and is suggested to be involved in the conversion of 3 to 1. This study deepens our understanding of cryptic secondary metabolism in A. oryzae.

PHENOLIC COMPOUNDS FROM ROOTS OF URTICA DIOICA

Root extracts from Urtica dioica were separated into several classes of compounds by extraction with organic solvents at different pH values.The phenolic fraction was analysed by GC-MS after trimethylsilylation.This procedure allowed the identification of 18 phenolic compounds as well as the detection of eight lignans.The occurrence of some of these substances in this plant was previously unknown.