203512-40-7

Upstream product

• 18166-02-4 N-trimethylsilylmethylamine 
• 589-15-1 1-bromomethyl-4-bromobenzene 

Downstream Products

• 203512-41-8 N-(4-bromobenzyl)-N-(trimethylsilylmethyl)aminomethyl methyl ether 
• 203512-84-9 3-[(3R,4S)-1-(4-Bromo-benzyl)-4-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]decane-4-carbonyl)-pyrrolidin-3-yl]-benzonitrile 
• 203512-47-4 (3S,4R)-1-[(2'-tert-butylaminosulfonyl-[1,1']-biphenyl-4-yl)methyl]-4-(3-cyanophenyl)pyrrolidin-3-ylcarboxylic acid 

Relevant academic research and scientific papers

Preparation of pyrrolidine and isoxazolidine benzamidines as potent inhibitors of coagulation factor Xa

The serine protease factor Xa is a critical enzyme in the blood coagulation cascade. Recently, the inhibition of factor Xa has begun to emerge as an attractive strategy for the discovery of novel antithrombotic agents. Here we describe pyrrolidine and isoxazolidine benzamidines as novel and potent inhibitors of factor Xa.

AMIDINOPHENYL-PYRROLIDINES, -PYRROLINES, AND -ISOXAZOLIDINES AND DERIVATIVES THEREOF

The present application describes amidinophenyl-pyrrolidines, -pyrrolines, and -isoxazolidines and derivatives thereof of formula (I), or pharmaceutically acceptable salt forms thereof, wherein one of D and D' may be C(=NH)NH2 and the other H and J and J may be O or CH2, which are useful as inhibitors of factor Xa.

Amidinophenyl-pyrrolidines, -pyrrolines, and -isoxazolidines and derivatives thereof

The present application describes amidinophenyl-pyrrolidines, -pyrrolines, and -isoxazolidines and derivatives thereof of formula I: or pharmaceutically acceptable salt forms thereof, wherein one of D and D' may be C(=NH)NH2 and the other H, and J1 and J2 may be O or CH2, which are useful as inhibitors of factor Xa.