Bioorganic and Medicinal Chemistry Letters p. 1195 - 1200 (1999)
Update date:2022-08-04
Topics:
Fevig, John M.
Buriak Jr., Joseph
Stouten, Pieter F. W.
Knabb, Robert M.
Gilbert N, Lam
Wong, Pancras C.
Wexler, Ruth R.
The serine protease factor Xa is a critical enzyme in the blood coagulation cascade. Recently, the inhibition of factor Xa has begun to emerge as an attractive strategy for the discovery of novel antithrombotic agents. Here we describe pyrrolidine and isoxazolidine benzamidines as novel and potent inhibitors of factor Xa.
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