20352-33-4Relevant academic research and scientific papers
Synthesis of cytotoxic 6E-hydroximino-4-ene steroids: Structure/activity studies
Deive,Rodríguez,Jiménez
, p. 2612 - 2618 (2001)
In an effort to determine the pharmaceutical utility and the structural requirements for activity against various tumor cell lines, several 6E-hydroximino-4-ene steroids with different side chains and degrees of unsaturation on ring A were synthesized in our laboratory. Evaluation of the synthesized compounds for cytotoxicity against P-388, A-549, HT-29, and MEL-28 tumor cells revealed that some important structural features are required for activity. The presence of a cholesterol-type side chain, which appears to play a major role in determining the biological activity, the existence of a ketone functionality at C-3, and an elevated degree of oxidation on ring A all result in higher bioctivity than other structural motifs.
Synthesis and plant growth promoting activity of polyhydroxylated ketones bearing the 5α-hydroxy-6-oxo moiety and cholestane side chain
Rosado-Abón, Anielka,De Dios-Bravo, Guadalupe,Rodríguez-Sotres, Rogelio,Iglesias-Arteaga, Martín A.
, p. 461 - 466 (2012/05/19)
Three polyhydroxylated ketones bearing the 5α-hydroxy-6-oxo moiety were obtained from cholesterol. Two of them show plant growth promoting activity in the bean's second internode bioassay. The obtained results indicate that the presence of the 5α-hydroxy-
Photochemistry of 3ζ,5ζ-Epoxycholestan-6-ones
Foster, Richard W. G.,Marples, Brian A.
, p. 579 - 581 (2007/10/02)
The photolysis of α-oxo-oxetanes appears to be controlled in part by stereoelectronic factors which require coplanarity of the α-cleaved oxetane bond with the singly or doubly occupied carbon p-orbital of the n,?* carbonyl group and the zwitterionic character of the initial bond cleaved species may be important.
