20358-08-1

Usage

Uses

Used in Pharmaceutical Drug Development:
Benzothiazole, 2-amino-7-fluoro(8CI) is used as a key component in the development of pharmaceutical drugs due to its potential medicinal properties. Its unique structure and functional groups allow it to be incorporated into various drug molecules, enhancing their therapeutic effects and targeting specific biological pathways.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, Benzothiazole, 2-amino-7-fluoro(8CI) serves as a valuable building block for the synthesis of various organic compounds. Its presence in these compounds can influence their chemical and biological properties, making it an essential tool for designing and optimizing new drug candidates.
Used in Drug Discovery:
Benzothiazole, 2-amino-7-fluoro(8CI) plays a crucial role in drug discovery, where it is utilized to explore new chemical entities with potential therapeutic applications. Its unique structure and functional groups make it an attractive starting point for the development of novel drugs, particularly in the areas of oncology, infectious diseases, and neurological disorders.
Used in Organic Synthesis:
As a versatile organic compound, Benzothiazole, 2-amino-7-fluoro(8CI) is used in organic synthesis to create a wide range of chemical products. Its reactivity and compatibility with various synthetic methods make it a valuable precursor for the preparation of complex organic molecules, including pharmaceuticals, agrochemicals, and specialty chemicals.

Upstream product

• 458-05-9 1-(3-fluorophenyl)thiourea 
• 17809-36-8 2-fluoro-6-nitroaniline 
• 399-31-5 N-(2-fluorophenyl)acetamide 
• 82635-62-9 1-benzoyl-3-(3-flourophenyl)thiourea 
• 372-19-0 meta-fluoroaniline 
• 333-20-0 potassium thioacyanate 
• 21325-05-3 1-fluoro-3-nitro-2-thiocyanatobenzene 

Downstream Products

• 100493-32-1 2-amino-6-fluorobenzenethiol 
• 100601-03-4 Acetic acid (2R,3R)-5-(2-dimethylamino-ethyl)-9-fluoro-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester 
• 100601-07-8 (2R,3R)-5-(2-Dimethylamino-ethyl)-9-fluoro-3-hydroxy-2-(4-methoxy-phenyl)-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one 
• 100493-29-6 (+/-)-cis-9-fluoro-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one 
• 100601-58-9 (+/-)-trans-(2R,3S)-9-fluoro-2,3-dihydro-3-hydroxy-2-(4'-methoxyphenyl)-1,5-benzothiazepin-4-[5H]-one 
• 100493-33-2 (2S,3S)-3-(2-Amino-6-fluoro-phenylsulfanyl)-2-hydroxy-3-(4-methoxy-phenyl)-propionic acid methyl ester 

Relevant academic research and scientific papers

THERAPEUTIC COMPOUNDS AND COMPOSITIONS

Compounds of general formula (I) and compositions comprising compounds of general formula I that modulate pyruvate kinase are described herein. Also described herein are methods of using the compounds that modulate pyruvate kinase in the treatment of diseases.

THERAPEUTIC COMPOUNDS AND COMPOSITIONS

Compounds of general formula (I) and compositions comprising compounds of general formula (I) that modulate pyruvate kinase are described herein. Also described herein are methods of using the compounds that modulate pyruvate kinase in the treatment of diseases.

THERAPEUTIC COMPOUNDS AND COMPOSITIONS

Compounds of general formula I: and compositions comprising compounds of general formula I that modulate pyruvate kinase are described herein. Also described herein are methods of using the compounds that modulate pyruvate kinase in the treatment of diseases.

N-(5-Fluorobenzothiazol-2-yl)-2-guanidinothiazole-4-carboxamide. A Novel, Systemically Active Antitumor Agent Effective against 3LL Lewis Lung Carcinoma

N-(5-Fluorobenzothiazol-2-yl)-2-guanidinothiazole-4-carboxamide (1) is a member of a series of amides found to substantially increase lifespan in mice bearing established micrometastatic 3LL Lewis lung carcinoma.Amide 1 is effective after either oral or i

Synthesis of Halogen-Substituted 1,5-Benzothiazepine Derivatives and Their Vasodilating and Hypotensive Activities

In an attempt to improve the effectiveness and duration of the action of diltiazem (1), a 1,5-benzothiazepine calcium channel blocker, its derivatives (2) with halogen substituents on the fused benzene ring were synthesized.These compounds were evaluated for their effects on vertebral and coronary blood flows and antihypertensive activity.The structure-activity relationships are discussed.The 8-chloro derivative ((+)-2b), the most potent compound in this series, was selected for clinical evaluation as a cerebral vasodilating and antihypertensive agent.