203643-16-7Relevant articles and documents
Synthesis and binding study of phosphonate analogues of PNAs and their hybrids with PNAs
Efimov, Vladimir A.,Choob, Michael V.,Buryakova, Alla A.,Chakhmakhcheva, Oksana G.
, p. 1671 - 1679 (2007/10/03)
The preparation of monomers for the synthesis of phosphonate analogues of peptide nucleic acids containing the four natural nucleobases: thymine, cytosine, adenine and guanine, has been accomplished. The monomers obtained were used for the automated online solid phase synthesis of pure phosphono- PNA oligomers as well as chimeras consisting of phosphono-PNA and PNA resudies. The hybridization properties of these oligonucleotide mimics to complementary DNA and RNA fragments were studied.