20366-59-0

Usage

Uses

Used in Organic Synthesis:
1-Bromo-5-methylnaphthalene is used as a reactant in organic synthesis for the preparation of various organic compounds. Its unique structure allows it to participate in a range of chemical reactions, making it a valuable component in the synthesis of complex organic molecules.
Used in Pharmaceutical Production:
In the pharmaceutical industry, 1-Bromo-5-methylnaphthalene is utilized as a building block for the production of pharmaceuticals. Its incorporation into the molecular structures of drugs contributes to their therapeutic properties, highlighting its importance in the development of new medications.
Used in Agrochemical Production:
Similarly, in the agrochemical sector, 1-Bromo-5-methylnaphthalene serves as a key component in the synthesis of various agrochemicals. Its role in the creation of effective pesticides and other agricultural products underscores its versatility and utility in this field.
Used in Chemical Research and Development:
1-Bromo-5-methylnaphthalene is also employed as a reagent in the production of intermediate and end products in the chemical industry. Its use in research and development facilitates the exploration of new chemical pathways and the creation of innovative chemical entities.
Used in Analytical Chemistry and Quality Control:
Furthermore, 1-Bromo-5-methylnaphthalene is used as a reference standard in analytical chemistry and quality control. Its precise properties make it an ideal benchmark for calibrating instruments and ensuring the accuracy of chemical analyses.
Safety Considerations:
Given its flammable nature, 1-Bromo-5-methylnaphthalene should be handled with caution. It is essential to work in a well-ventilated area and to use appropriate personal protective equipment to minimize risks associated with its use.

InChI:InChI=1/C11H9Br/c1-8-4-2-6-10-9(8)5-3-7-11(10)12/h2-7H,1H3

Upstream product

• 102878-61-5 5-methylnaphthalene-1-amine 
• 77332-64-0 5-bromo-1-iodonaphthalene 
• 20366-58-9 1-Bromo-5-(chloromethyl)naphthalene 
• 91182-49-9 1-Brom-5-iodmethylnaphthalin 
• 68449-30-9 5-bromo-1-tetralone 
• 59866-97-6 5-bromo-1-naphthoic acid methyl ester 
• 108-36-1 1,3-dibromobenzene 
• 534-22-5 2-methylfuran 
• 151109-14-7 1-bromo-5-(bromomethyl)naphthalene 
• 1587-04-8 1-methyl-2-(2-propenyl)-benzene 
• 7351-74-8 1,5-dibromonaphthalene 
• 74-88-4 methyl iodide 
• 16726-67-3 5-bromo-1-naphthalenecarboxylic acid 
• 4766-33-0 5-amino-1-bromonaphthalene 

Downstream Products

• 571-61-9 1,5-dimethylnaphthalene 
• 4527-60-0 5-methyl-1-naphthoic acid 
• 65755-12-6 2-(5-methyl-[1]naphthyl)-ethanol 
• 104306-72-1 5-methyl-1-naphthaldehyde 

Relevant academic research and scientific papers

Syntheses of 1-bromo-8-methylnaphthalene and 1-bromo-5-methylnaphthalene

The Diels-Alder reaction between 2-methylfuran and 3-bromobenzyne (3), which was generated under mild conditions from 1,3-dibromobenzene and lithium diisopropylamide (LDA), gives a mixture of regioisomeric 1,4-dihydro-1,4-epoxynaphthalenes 4 and 5. A subsequent two-step deoxygenation affords the corresponding 1-bromo-8-methylnaphthalene (1) and 1-bromo-5-methylnaphthalene (2) in high yields.

A Visible Light and Iron-mediated Carbocationic Route to Polysubstituted 1-Halonaphthalenes by Benzannulation using Allylbenzenes and Polyhalomethanes

A wide array of polysubstituted 1-bromo and chloronaphthalenes are obtained from coupling of allylbenzenes and polyhalomethanes. The reaction is mediated by iron metal under visible light irradiation and proceeds via a Kharasch addition intermediate followed by intramolecular FeIII mediated Friedel-Crafts alkylation, with the formation of two Csp2?Csp2 bonds in the process. This method gives easy access to 1-halonaphthalenes with substituent(s) at C-5 to C-8 that are otherwise hard to synthesize. (Figure presented.).

KRAS G12C INHIBITORS

The present invention relates to compounds that, inhibit KRas G12C, In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.

COMPOUNDS FOR BINDING PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (PCSK9)

The present disclosure relates to novel compounds, methods, and compositions capable of binding to PCSK9, thereby modulating PCSK9 proprotein convertase enzyme activity. The compounds of the disclosure include compounds Formula (I).

Diastereoselective synthesis of β-aryl-C-nucleosides from 1,2-anhydrosugars

(Chemical Equation Presented) The cis opening of glycal epoxides with arylaluminum reagents provides strict stereocontrol in C-glycosylation. β-Aryl-C-2-deoxynucleosides are obtained from known glycals by an epoxidation-glycosylation-deoxygenation sequenc

Dihydropyrimidine derivatives

Novel A-II receptor antagonists have the formula STR1 or its isomer STR2 wherein R1, R2, R3, R4, R5, and R6, are as defined herein. These compounds inhibit the action of angiotensin II and are useful, therefore, for example, as antihypertensive agents.