20368-65-4Relevant academic research and scientific papers
Synthesis of sulfanylidene-diazaspirocycloalkanones in a three-component Mannich-type reaction catalyzed with lactic acid
Jagodziński, Tadeusz S.,So?nicki, Jacek G.,Struk, ?ukasz
, p. 43 - 57 (2017/07/26)
The aminomethylation of thioamides containing an acidic hydrogen atom at the a-carbon atom was investigated as a general reaction. Spirohexahydropyrimidines were obtained in the one-pot, three-component reaction of a variety of cyclic-ketone-derived thioamides, primary amines and formaldehyde with lactic acid acting as a catalyst. The results of our experiments confirmed the high catalytic efficiency of lactic acid. A proper choice of the starting thioamides and amines makes it possible to use this reaction methodolgy to synthesize several new and potentially useful derivatives of hexahydropyrimidine, e.g., biologically-active compounds.
