28870-29-3

Upstream product

• 50706-60-0 3-amino-4-cyano-1-phenylimino-5,6,7,8-tetrahydroisothiachromene 
• 78171-69-4 2-morpholino-cyclohexen-1-carbothionic acid anilide 
• 109-77-3 malononitrile 
• 20368-65-4 cyclohexan-2-one-1-carbothionic acid anilide 
• 4354-73-8 2-(cyclohexylidene)malononitrile 
• 103-72-0 phenyl isothiocyanate 

Downstream Products

• 28870-35-1 3-amino-1-oxo-2-phenyl-1,2,5,6,7,8-hexahydroisoquinoline-4-carbonitrile 

Relevant academic research and scientific papers

Efficient Synthesis and Some Transformations of 1-Hydrazinyl-5,6,7,8-tetrahydroisoquinolines Involving Rearrangement of the Pyridine Ring

—A procedure was developed for the synthesis of 1-hydrazinyl-3-arylamino-5,6,7,8-tetrahydroisoquinoline- 4-carbonitriles via recyclization of the pyridine ring in 3-amino-2-aryl-1-sulfanylidene-1,2,5,6,7,8- hexahydroisoquinoline-4-carbonitriles by the act

Novel synthesis of 1,8-alkanopyrido-[3,4-d]pyridazine: A new ring system

Cycloalkylidenemalononitriles couple with various diazonium salts to yield the corresponding cycloalkeno[c]pyridazines, which react with trichloroacetonitrile to give the 1,8-alkanopyrido[3,4-d]pyridazines. The reaction of cycloalkenopyridazines with DMF dimethylacetal gives enamine derivatives, which can be converted to 1,8-alkanopyrido[3,4-d]pyridazines via treating with hydrazine hydrate or aromatic amines. Substituted cycloalkenopyridines react with diazoaminobenzene to afford the corresponding 1,8-alkanopyridopyridazines.

The Knoevenagel Reaction of Malononitrile with Some Cyclic β-Ketocarbothionic Acid Anilides. Synthesis of Cycloalkeno-pyridines and Cycloalkeno-thiopyrans

A new route to the cycloalkeno-pyridines 2 and cycloalkeno-thiopyrans 5 by the reaction of malononitrile with enamines of cyclic β-ketocarbothionic acid anilides is presented.The elucidation of the structure of compounds obtained is based on MS spectral d

Reaction of Methylene Active Nitriles and Cyanamide with Acylated Enamines

The addition products from enamines onto isocyanates and isothiocyanates, i.e. substituted β-aminoacrylo amides 1 and thioamides 2, react with malononitrile to yield the 6-amino-1-aryl-5-cyano-pyridin-2-ones 3 and -thiones 4 among them 5,6,7,8-tetrahydroi