20374-33-8Relevant academic research and scientific papers
PANTETHENOYLCYSTEINE DERIVATIVES AND USES THEREOF
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Paragraph 3270, (2020/10/20)
The present disclosure relates to compounds of Formula (I) or (II): (Formulae (I), (II)), and pharmaceutically acceptable salts or solvates thereof. The present disclosure also relates to pharmaceutical compositions comprising the compounds and therapeutic and diagnostic uses of the compounds and pharmaceutical compositions.
Total Synthesis of Bryostatin 8 Using an Organosilane-Based Strategy
Zhang, Yuebao,Guo, Qianyou,Sun, Xianwei,Lu, Ji,Cao, Yanjun,Pu, Qiang,Chu, Zhiwen,Gao, Lu,Song, Zhenlei
supporting information, p. 942 - 946 (2017/12/26)
Convergent total synthesis of bryostatin 8 has been accomplished by an organosilane-based strategy. The C ring is constructed stereoselectively through a geminal bis(silane)-based [1,5]-Brook rearrangement, and the B ring through geminal bis(silane)-based Prins cyclization, thus efficiently joining the northern and southern parts of the molecule.
Enantiodivergent syntheses of pantolactone and pantothenic acid from d -mannitol
Sanyal, Ishita,Barman, Piyalideb,Banerjee, Asishkumar
, p. 1102 - 1108 (2012/05/04)
Efficient synthetic routes to both the enantiomers of pantolactone and pantothenic acid have been developed starting from d-mannitol-based d-glyceraldehyde acetonide through its conversion into a protected pantoic acid intermediate followed by either cyclization or amide bond formation with a -amino ester, and subsequent appropriate deprotection. Georg Thieme Verlag Stuttgart . New York.
Formal total synthesis of cyanolide a
Pabbaraja, Srihari,Satyanarayana,Ganganna,Yadav
supporting information; experimental part, p. 1922 - 1925 (2011/06/20)
Formal total synthesis of cyanolide A, aglycosidic dimeric macrolide is accomplished. The key reactions involved are asymmetric acetate aldol reaction, CBS reduction, and Shiina's lactonization.
Synthesis of molluscicidal agent cyanolide a macrolactone from D-(-)-Pantolactone
Hajare, Atul K.,Ravikumar, Velayutham,Khaleel, Shaik,Bhuniya, Debnath,Reddy, D. Srinivasa
supporting information; experimental part, p. 963 - 966 (2011/04/18)
An efficient synthesis of potent molluscicidal agent cyanolide A, a glycosidic 16-membered macrolide, starting from D-(-)-pantolactone is reported. Highly stereoselective aldol, oxa-Michael addition, and Yamaguchi macrolactonization are the key steps in the present synthesis.
An asymmetric synthesis of carboxylic acid derivatives, including lactic acid and α-amino acid derivatives, from optically active 1-chlorovinyl p-tolyl sulfoxides and ester lithium enolates with creation of chirality at the α-position
Kido, Masahiro,Sugiyama, Shimpei,Satoh, Tsuyoshi
, p. 1934 - 1947 (2008/02/13)
Treatment of optically active 1-chlorovinyl p-tolyl sulfoxides, which were synthesized from symmetrical ketones or methyl formate and (R)-(-)-chloromethyl p-tolyl sulfoxide in three steps, with lithium enolate of carboxylic acid tert-butyl esters gave opt
HIV INTEGRASE INHIBITORS
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Page/Page column 83-84, (2008/06/13)
Tricyclic compounds of Formula (I) are inhibitors of HIV integrase and inhibitors of HIV replication: wherein bond a, ring A, Rl, R2 and R3 are defined herein. The compounds are useful for the prophylaxis or treatment of infection by HIV and the prophylaxis, treatment, or delay in the onset of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.
Modular synthesis of pantetheine and phosphopantetheine
Mandel, Alexander L.,La Clair, James J.,Burkart, Michael D.
, p. 4801 - 4803 (2007/10/03)
(Chemical Equation Presented) D-Pantetheine and D-phosphopantetheine, precursors to coenzyme A, have been synthesized though a linear sequence from three modules (M1-M3) in 9 and 10 steps, respectively. These routes provide access to analogues of coenzyme A containing modified cystamines, β-alanines, and pantoic acid residues. All three modules were joined using conventional methods of peptide synthesis. The chiral component, M3, was derived from D-pantolactone.
Synthesis of the C(1)-C(16) fragment of bryostatins
O'Brien, Matthew,Taylor, Nicholas H,Thomas, Eric J
, p. 5491 - 5494 (2007/10/03)
A synthesis of the C(1)-C(16) fragment 43 of the bryostatins is reported which features a stereoselective equivalent of an 'ene' reaction between the allylsilane 35 and the alkynone 33 and the stereoselective conjugate addition-cyclisation of the dienyl k
