203740-63-0

Usage

Uses

Used in Bioconjugation:
Propargyl-PEG3-Bromide is used as a bioconjugation agent for the attachment of various biomolecules, such as proteins, peptides, and nucleic acids, to other molecules or surfaces. The stable triazole linkage formed through Click Chemistry ensures the covalent and specific binding of the biomolecules.
Used in Drug Delivery Systems:
Propargyl-PEG3-Bromide is used as a component in the design and synthesis of drug delivery systems, such as nanoparticles, liposomes, and hydrogels. The presence of the propargyl group allows for the incorporation of drugs or other therapeutic agents into these systems through Click Chemistry, enabling targeted and controlled drug delivery.
Used in Materials Science:
Propargyl-PEG3-Bromide is used as a building block in the synthesis of functional materials, such as polymers, dendrimers, and self-assembled structures. The propargyl group can be used to create complex architectures and networks through Click Chemistry, allowing for the development of materials with specific properties and applications.
Used in Chemical Synthesis:
Propargyl-PEG3-Bromide is used as an intermediate in the synthesis of various organic compounds, including pharmaceuticals, agrochemicals, and specialty chemicals. The propargyl group can be further modified or functionalized through Click Chemistry, providing a versatile platform for the development of new chemical entities.

Upstream product

• 31255-10-4 1,2-bis-(2-bromo-ethoxy)-ethane 
• 107-19-7 propargyl alcohol 
• 112-27-6 2,2'-[1,2-ethanediylbis(oxy)]bisethanol 
• 208827-90-1 O-propargyl triethylene glycol 

Relevant academic research and scientific papers

COMPOSITIONS AND METHODS RELATED TO MOLECULAR CONJUGATION

The invention relates to activated Michael acceptor (AMA) compounds that can undergo conjugation with biomolecules containing Michael donor moieties, thereby providing plasma-stable antibody-drug conjugates (ADCs). Pharmaceutical compositions of the ADCs are disclosed as well. Also provided herein are a number of applications (e.g., therapeutic applications) in which the compositions are useful.

MERTK DEGRADERS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

Organic metal-complexes. XXI [1]: Synthesis and structure of 3,5,15,17-tetraoxo-1,7,10,13,19,22-hexaoxacyclotetracosane and 2,12,14,24-tetraoxo-4,7,10,16,19,22-hexaoxa-25-mercurato-bicyclo[11.11.1] pentacosane

A new synthesis of the title crown via isoxazolo crown ether 7 and macrocyclic bis-β-eneaminoketone 10 is described. 7 can be synthesized in 14% yield by a non-template double-[3+2] cycloaddition of dinitrileoxide 5 prepared in situ from dinitropolyether 19 by dehydration with Ph-NCO and alkyne 6. The compounds 16, 17 and 18 are synthesized by the same synthetic strategy. Comparable IR and 1H NMR spectroscopic data of macrocyclic and non-cyclic compounds show, that macrocyclic conformation stabilizing effects can be ruled out. The structures of the macrocycles 1, 7, 10 and that of the Hg(II)-complex25, synthesized by reaction of 1 with Hg(OAc)2 were established by single-crystal X-ray structure analyses. Both inter- and intramolecular hydrogen bonds are observed for the macrocyclic bis-β-eneaminoketone 10, whereas only intramolecular hydrogen bonds are formed by 1. In the Hg(II)-complex of 1 the mercury is bonded to two methylene groups. C-Hg-C is almost linear [177(1)°], the mean Hg-C distance amounts to 215(1) pm. In addition to the Hg-C bonds, each Hg makes a short contact to a carbonyl oxygen in a neighbouring molecule in the plane perpendicular to the C-Hg-C axis [Hg(1)-O(1)=279(1) pm, Hg(2)-O(5)= 284(1) pm]. Johann Ambrosius Barth 1998.