203869-80-1 Usage
General Description
BOC-ALPHA-ALLYL-ME-DL-PRO-OH is a chemical compound that contains a BOC (tert-butoxycarbonyl) protecting group, an alpha-amino group, an allyl functional group, a methyl group, and a proline derivative. The BOC group is commonly used as a protecting group for amines in organic synthesis, allowing for selective deprotection at a later stage. The allyl and methyl groups are both commonly found in organic compounds, with the allyl group being a versatile functional group that can participate in various chemical reactions. The proline derivative is a derivative of the amino acid proline, which is often used in peptide synthesis and as a chiral building block in organic chemistry. Overall, BOC-ALPHA-ALLYL-ME-DL-PRO-OH is a complex chemical compound with various functional groups that can be used in a wide range of organic synthesis applications.
Check Digit Verification of cas no
The CAS Registry Mumber 203869-80-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,3,8,6 and 9 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 203869-80:
(8*2)+(7*0)+(6*3)+(5*8)+(4*6)+(3*9)+(2*8)+(1*0)=141
141 % 10 = 1
So 203869-80-1 is a valid CAS Registry Number.
InChI:InChI=1/C11H19NO4/c1-10(2,3)16-9(15)12-7-5-6-11(12,4)8(13)14/h5-7H2,1-4H3,(H,13,14)
203869-80-1Relevant articles and documents
Interrupted Curtius Rearrangements of Quaternary Proline Derivatives: A Flow Route to Acyclic Ketones and Unsaturated Pyrrolidines
Baumann, Marcus,Moody, Thomas S.,Smyth, Megan,Wharry, Scott
, p. 14199 - 14206 (2021/07/20)
Conversion of N-Boc-protected quaternary proline derivatives under thermal Curtius rearrangement conditions was found to afford a series of ring-opened ketone and unsaturated pyrrolidine products instead of the expected carbamate species. The nature of the substituent on the quaternary carbon thereby governs the product outcome due to the stability of a postulated N-acyliminium species. A continuous flow process with in-line scavenging was furthermore developed to streamline this transformation and safely create products on a gram scale.
Structure-reactivity relationships of l-proline derived spirolactams and α-methyl prolinamide organocatalysts in the asymmetric Michael addition reaction of aldehydes to nitroolefins
Kelleher, Fintan,Kelly, Sinead,Watts, John,McKee, Vickie
experimental part, p. 3525 - 3536 (2010/06/17)
l-Proline derived spirolactams and α-methyl prolinamides act as organocatalysts for the asymmetric conjugate addition of aldehydes to nitroolefins in excellent yields, with good diastereoselectivity and enantioselectivity. Furthermore, low catalyst loadings (5 mol %) and a low aldehyde molar excess (1.5 M equiv) were achieved.
