20412-92-4

Upstream product

• 104-88-1 4-chlorobenzaldehyde 
• 614-16-4 Benzoylacetonitrile 
• 93-89-0 benzoic acid ethyl ester 

Downstream Products

• 104-88-1 4-chlorobenzaldehyde 
• 614-16-4 Benzoylacetonitrile 
• 95104-56-6 5-Benzoyl-4,6-bis-(4-chloro-phenyl)-2-thioxo-hexahydro-pyrimidine-5-carbonitrile 
• 95104-60-2 5-Benzoyl-4,6-bis-(4-chloro-phenyl)-2-oxo-hexahydro-pyrimidine-5-carbonitrile 
• 108463-31-6 5-Acetyl-4-(4-chloro-phenyl)-6-hydroxy-1,2-diphenyl-1,4-dihydro-pyridine-3-carbonitrile 
• 76593-41-4 5-(4-Chloro-phenyl)-4-cyano-3-hydroxy-3-phenyl-tetrahydro-thiophene-2-carboxylic acid methyl ester 
• 117135-04-3 5-(4-chlorophenyl)-6-cyano-2-methyl-7-phenyl-s-triazolo<1,5-a>pyrimidine 
• 76593-47-0 5-(4-Chloro-phenyl)-4-cyano-3-hydroxy-3-phenyl-tetrahydro-thiophene-2-carboxylic acid ethyl ester 
• 142532-09-0 5-(4-Chloro-phenyl)-2,3,7-triphenyl-5H-imidazo[2,1-b][1,3]thiazine-6-carbonitrile 
• 75238-82-3 3,5-dicyano-6-hydroxy-4-(p-chlorophenyl)-6-phenyl-2-piperidone 
• 133149-62-9 9-Amino-8-benzoyl-7-(4-chloro-phenyl)-11-oxo-11H-pyrido[2,1-b]quinazoline-6-carbonitrile 
• 75239-01-9 3,5-dicyano-4-(p-chlorophenyl)-6-phenyl-2-pyridone 
• 78482-15-2 3,5-dicyano-4-(p-chlorophenyl)-6-phenyl-3,4-dihydro-2-pyridone 

Relevant academic research and scientific papers

Organocatalytic Asymmetric [4+2] Cycloaddition of 1-Acetylcyclopentene and 1-Acetylcyclohexene for the Synthesis of Fused Carbocycles

The first organocatalytic asymmetric [4+2]-cycloaddition reaction of 1-acetylcyclopentenes and 1-acetylcyclohexenes was developed. Enones having cyano groups were used as the dienophiles in this method. The reaction provides a useful practical route to th

Imidazolium ylide mediated tandem Knoevenagel–Michael–O-cyclization sequence for the synthesis of multi-substituted 4,5-dihydrofurans

The stereoselective syntheses of novel trans-5-aroyl-2,4-diaryl-4,5-dihydrofuran-3-carbonitriles have been achieved via a one-pot, three-component tandem protocol involving aroyl acetonitriles, aromatic aldehydes, and imidazolium ylide in the presence of

Magnesium Halide-Catalyzed Synthesis of Oxaspiro[2.5]octenes from a Methylenecyclopropane and Acyl Cyanoalkenes

MgX2-catalyzed annulation of methylenecyclopropanes with acyl cyanoalkenes was accomplished to give oxaspiro[2.5]octenes in excellent yields. The reaction proceeded through a rare intramolecular oxa-Michael addition of Mg enolate. The oxaspiro

Substituent-Controlled Divergent Cascade Cycloaddition Reactions of Chalcones and Arylalkynols: Access to Spiroketals and Oxa-Bridged Fused Heterocycles

Herein, we report substituent-controlled divergent cascade cycloaddition reactions of chalcones and arylalkynols in the presence of PtI2. Depending on the substituent on the chalcone, either spiroketals or oxa-bridged fused heterocycles could be obtained in the ranges of 86–97% and 87–95% yields under identical reaction conditions. Control experiments were carried out to elucidate the origin of the high chemoselectivity. These provide a method for the synthesis of a diverse array of structurally complex oxygen-containing heterocycles. (Figure presented.).

Dienamine-Mediated Asymmetric Inverse-Electron-Demand Hetero-Diels–Alder Reaction of Linear Deconjugated Enones: Diversity-Oriented Synthesis of 3,4-Dihydropyrans

The first organocatalytic asymmetric inverse-electron-demand Diels–Alder reaction of deconjugated enones by using a linear dienamine was explored. Electron-poor oxadienes having a cyano group were found to be suitable in this reaction. With a 20 mol-% loa

Tandem cross-Rauhut-Currier/cyclization reactions of activated alkenes to give densely functionalized 3,4-dihydropyrans

A novel tandem cross-Rauhut-Currier/cyclization reaction between α,β-unsaturated ketones was developed. Using DABCO (20 mol %) as the catalyst, a series of densely functionalized 3,4-dihydropyrans were obtained in excellent yields and stereoselectivities (up to 98% yield, >99:1 dr). A tentative catalytic cycle was proposed with key intermediates confirmed by ESIMS studies.