204122-18-9Relevant academic research and scientific papers
Synthesis and evaluation of a set of 4-Phenylpiperidines and 4-Phenylpiperazines as D2 receptor ligands and the discovery of the dopaminergic stabilizer 4-[3-(Methylsulfonyl)phenyl]-l-propylpiperidine (huntexil, pridopidine, ACR16)
Pettersson, Fredrik,Ponten, Henrik,Waters, Nicholas,Waters, Susanna,Sonesson, Clas
supporting information; experimental part, p. 2510 - 2520 (2010/08/22)
Modification of the partial dopamine type 2 receptor (D2) agonist 3-(l-benzylpiperidin-4-yl)phenol (9a) generated a series of novel functional D2 antagonists with fast-off kinetic properties. A representative of this series, pridopid
New generation dopaminergic agents. 2. Discovery of 3-OH-phenoxyethylamine and 3-OH-N1-phenylpiperazine dopaminergic templates
Mewshaw, Richard E.,Husbands, Morris,Gildersleeve, Elizabeth S.,Webb, Michael B.,Shi, Xiaojie,Mazandarani, Hossein,Cockett, Mark I.,Ochalski, Rafal,Brennan, Julie A.,Abou-Gharbia, Magid,Marquis, Karen,McGaughey, Georgia B.,Coupet, Joseph,Andree, Terrance H.
, p. 295 - 300 (2007/10/03)
Described in this report is a systematic study which led to the identification of two new dopamine D2 partial agonists (5 and 17). Phenols 5 and 17 represent prototypes of two new classes of D2 partial agonist as well as templates for the future design of novel dopaminergic agents.
