204253-96-3Relevant academic research and scientific papers
Synthesis of natural PI(3,4,5)P3
Watanabe, Yutaka,Nakatomi, Mitsunobu
, p. 1583 - 1586 (1998)
Natural phosphatidylinositol 3,4,5-trisphosphate which has been believed to have stearoyl and arachidonoyl groups at the sn-1 and -2 positions, respectively, has been synthesized using 1,2-O-cyclohexylidene 3,4-O-disiloxanyl-myo-inositol as the pivotal intermediate.
Synthesis of PI(3,4,5)P3 with unsaturated and saturated fatty acid chains
Watanabe, Yutaka,Nakatomi, Mitsunobu
, p. 9743 - 9754 (1999)
Synthesis of three PI(3,4,5)P3s, sn-1-O-stearoyl-sn-2-O-arachidonoyl, stearoyl-linolenoyl, and distearoyl phosphatidyl-myo-inositol 3,4,5- trisphosphate with the natural configuration for the arachidonoyl version was established by employing 9-fluorenylmethyl-protected phosphate derivatives.
Resolution of synthetically useful myo-inositol derivatives using the chiral auxiliary O-acetylmandelic acid
Sureshan, Kana M.,Kiyosawa, Yoko,Han, Fushe,Hyodo, Sayuri,Uno, Yuhki,Watanabe, Yutaka
, p. 231 - 241 (2007/10/03)
Efficient methods for the resolution of various myo-inositol derivatives have been developed using O-acetylmandelic acid (OAM) as the chiral auxiliary. Various methods of introduction of the chiral auxiliary have been compared. DCC mediated coupling betwe
Chemical Resolution of 1,2-O-Cyclohexylidene-3,4-O-(tetraisopropyldisiloxane-1,3-diyl)-myo-inositol and Synthesis of Phosphatidyl-D-myo-inositol 3,5-Bisphosphate from Both L- and D-Enantiomers
Han, Fushe,Hayashi, Minoru,Watanabe, Yutaka
, p. 558 - 566 (2007/10/03)
Chemical resolution of a versatile starting material, 1,2-O-cyclohexylidene-3,4-O-(tetraisopropyldisiloxane-1,3-diyl)-myo-inositol, which is used to access naturally occurring inositol phosphates and phosphatidylinositol phosphates, is described. Starting
