20426-63-5

Upstream product

• 953395-38-5 4-(2-(4-methylphenylsulfonamido)phenyl)butyl 4-pentynoate 
• 953395-39-6 4-(2-(4-methylphenylsulfonamido)phenyl)butyl 2-ethynylbenzoate 
• 1118507-54-2 C₁₇H₁₇NO₂S 
• 98-59-9 p-toluenesulfonyl chloride 
• 209967-17-9 4-(2-aminophenyl)-1-butanol 
• 953395-35-2 N-[2-(4-hydroxy-butyl)-phenyl]-4-methyl-benzenesulfonamide 

Downstream Products

• 24310-36-9 1-tosyl-2,3,4,5-tetrahydro-1H-1-benzazepin-5-one 
• 585578-16-1 1-(p-toluenesulfonyl)-2H,3H,4H,1aH,8bH-benzo[f]oxirane[2,3-d]azaperhydroepine 

Relevant academic research and scientific papers

Sequential aza-Claisen rearrangement and ring-closing metathesis as a route to 1-benzazepine derivatives

A synthetic strategy based on sequential application of aza-Claisen rearrangement and ring-closing metathesis reaction as key steps has been developed for the synthesis of various 1-benzazepine derivatives of pharmaceutical relevance. Georg Thieme Verlag

Catalytic activation of the leaving group in the SN2 reaction

A novel catalytic activation of the leaving group in the SN2 reaction is achieved as an extension of our mercuric triflate-catalyzed reactions. Derivatives of anilinoethyl 4-pentynoate reacted smoothly with catalytic amounts of Hg(OTf)2 to give indoline derivatives in excellent yield with efficient catalytic turnovers under very mild conditions. The reaction of optically pure secondary alcohol derivatives resulted in inversion of stereochemistry, which is a definitive feature of the S N2 reaction. The procedure is applicable for benzoazepine synthesis.