953395-35-2Relevant academic research and scientific papers
Biomimetic aerobic oxidation of amino alcohols to lactams
Babu, Beneesh P.,Endo, Yoshinori,Baeckvall, Jan-E.
supporting information, p. 11524 - 11527,4 (2012/12/11)
The right path: N-Protected amino alcohols undergo aerobic and biomimetic oxidation to the corresponding lactams in the presence of a ruthenium catalyst and a combination of electron-transfer mediators under air (see scheme). The reaction was used for the synthesis of five-, six-, and seven-, membered lactams and showed good tolerance to a number of N-protecting groups. Copyright
Catalytic activation of the leaving group in the SN2 reaction
Yamamoto, Hirofumi,Pandey, Ghanshyam,Asai, Yumiko,Nakano, Mayo,Kinoshita, Atsushi,Namba, Kosuke,Imagawa, Hiroshi,Nishizawa, Mugio
, p. 4029 - 4032 (2008/02/10)
A novel catalytic activation of the leaving group in the SN2 reaction is achieved as an extension of our mercuric triflate-catalyzed reactions. Derivatives of anilinoethyl 4-pentynoate reacted smoothly with catalytic amounts of Hg(OTf)2 to give indoline derivatives in excellent yield with efficient catalytic turnovers under very mild conditions. The reaction of optically pure secondary alcohol derivatives resulted in inversion of stereochemistry, which is a definitive feature of the S N2 reaction. The procedure is applicable for benzoazepine synthesis.
Efficient synthesis of functionalized benzazepine derivatives utilizing intramolecular mitsunobu reaction
Ohtani, Tadaaki,Kawano, Yoshikazu,Kitano, Kazuyoshi,Matsubara, Jun,Komatsu, Makoto,Uchida, Minoru,Tabusa, Fujio,Nagao, Yoshimitsu
, p. 481 - 502 (2007/10/03)
The 5-hydroxy-2,3,4,5-tetrahydro-1H-benzazepine derivative (2), which is a typical metabolite of mozavaptan (1) having the 2,3,4,5-tetrahydro-1H-benzazepine skeleton, was synthesized by utilizing the intramolecular Mitsunobu reaction of the corresponding
