209967-17-9

Upstream product

• 74117-98-9 4-(2-amino-phenyl)-butyric acid ethyl ester 
• 209967-16-8 4-(o-nitrophenyl)-3-butyne-1-ol 
• 609-73-4 o-nitroiodobenzene 
• 1221498-35-6 4-(2-nitrophenyl)-butyraldehyde 
• 4424-80-0 2,3,4,5-tetrahydro-1H-1-benzo[b]azepin-2-one 
• 52103-12-5 3-iodopropyl tetrahydro-2H-pyran-2-yl ether 
• 74965-31-4 N-(tert-butoxycarbonyl)-o-toluidine 

Downstream Products

• 1701-57-1 2,3,4,5-tetrahydro-1Hbenzo[b]azepine 
• 953395-35-2 N-[2-(4-hydroxy-butyl)-phenyl]-4-methyl-benzenesulfonamide 
• 953395-38-5 4-(2-(4-methylphenylsulfonamido)phenyl)butyl 4-pentynoate 
• 953395-39-6 4-(2-(4-methylphenylsulfonamido)phenyl)butyl 2-ethynylbenzoate 
• 20426-63-5 1-(p-Tolylsulfonyl)-2,3,4,5-tetrahydro-1H-1-benzazepine 
• 1093413-28-5 4-(o-iodophenyl)butan-1-ol 
• 881417-15-8 1-(p-toluenesulfonyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one 

Relevant academic research and scientific papers

Formal Deoxygenative Hydrogenation of Lactams Using PNHP-Pincer Ruthenium Complexes under Nonacidic Conditions

A formal deoxygenative hydrogenation of amides to amines with RuCl2(NHC)(PNHP) (NHC = 1,3-dimethylimizadol-2-ylidene, PNHP = bis(2-diphenylphosphinoethyl)amine) is described. Various secondary amides, especially NH-lactams, are reduced with H2 (3.0-5.0 MPa) to amines at a temperature range of 120-150 °C with 1.0-2.0 mol % of PNHP-Ru catalysts in the presence of Cs2CO3. This process consists of (1) deaminative hydrogenation of secondary amides to generate primary amines and alcohols, (2) dehydrogenative coupling of the transient amines with alcohols to generate imines, and (3) hydrogenation of imines to give the formally deoxygenated secondary amine products.

Macrolide Synthesis through Intramolecular Oxidative Cross-Coupling of Alkenes

A RhIII-catalyzed intramolecular oxidative cross-coupling between double bonds for the synthesis of macrolides is described. Under the optimized reaction conditions, macrocycles containing a diene moiety can be formed in reasonable yields and with excellent chemo- and stereoselectivity. This method provides an efficient approach to synthesize macrocyclic compounds containing a 1,3-conjugated diene structure.

A mild inter- and intramolecular amination of aryl halides with a combination of CuI and CsOAc

A unique combination of CuI and CsOAc was found to catalyze aryl amination under mild conditions. The reaction takes place at room temperature or at 90 °C with broad functional group compatibility. The intramolecular reaction was able to form five-, six-, and seven-membered rings with various protecting groups on the nitrogen atom. The scope of the intermolecular amination, as well as its applications to unsymmetrical N,N′-dialkylated phenylenediamines, was investigated.

Oxidative cyclization of amino alcohols catalyzed by a Cp*lr complex. Synthesis of indoles, 1,2,3,4-tetrahydroquinolines, and 2,3,4,5-tetrahydro-1-benzazepine

A new iridium-catalyzed oxidative cyclization of amino alcohols has been revealed. Indole derivatives are synthesized in good to excellent yields from 2-aminophenethyl alcohols by means of a [Cp*IrCl2]2/K2CO3 catalytic system. The present catalytic system is also effective for syntheses of 1,2,3,4-tetrahydroquinolines from 3-(2-aminophenyl)propanols and 2,3,4,5-tetrahydro-1-benzazepine from 4-(2-aminophenyl)butanol.