204275-01-4Relevant academic research and scientific papers
PHOSPHINIC ACID AMIDES AS MATRIX METALLOPROTEASE INHIBITORS
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, (2008/06/13)
The invention provides compounds which are useful as inhibitors of matrix metalloproteases, and which are effective in treating conditions characterized by excess activity of these enzymes. In particular, the present invention relates to a compound having
Design and synthesis of phosphinamide-based hydroxamic acids as inhibitors of matrix metalloproteinases
Pikul, Stanislaw,McDow Dunham, Kelly L.,Almstead, Neil G.,De, Biswanath,Natchus, Michael G.,Anastasio, Melanie V.,McPhail, Sara J.,Snider, Catherine E.,Taiwo, Yetunde O.,Chen, Longyin,Dunaway, C. Michelle,Gu, Fei,Mieling, Glen E.
, p. 87 - 94 (2007/10/03)
A new series of hydroxamic acid-based matrix metalloproteinase (MMP) inhibitors containing a unique phosphinamide motif derived from D-amino acid was designed, synthesized, and tested for enzyme inhibition. Compounds with an R configuration at phosphorus
PHOSPHINIC ACID AMIDES AS MATRIX METALLOPROTEASE INHIBITORS
-
, (2008/06/13)
The invention provides compounds which are useful as inhibitors of matrix metalloproteases, and which are effective in treating conditions characterized by excess activity of these enzymes. In particular, the present invention relates to a compound having
