20433-21-0Relevant academic research and scientific papers
5-substituted-2-2H-tetrazoleamine manufacturing method
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Paragraph 0041-0042; 0046; 0057, (2021/09/18)
The present invention is a method for producing a 5-substituted-2-aryl-2H-tetrazole that is useful as an intermediate for producing a pharmaceutical compound, and relates to a method which selectively introduces an aryl group in the 2 position.
Efficient synthesis of 2,5-disubstituted tetrazoles via the Cu 2O-catalyzed aerobic oxidative direct cross-coupling of N-H free tetrazoles with boronic acids
Li, Yu,Gao, Lian-Xun,Han, Fu-She
supporting information; experimental part, p. 2719 - 2721 (2012/03/27)
We present a new protocol that allows for the synthesis of 2,5-disubstituted tetrazoles via the direct coupling of N-H free tetrazoles and low toxic boronic acids in the presence of only a catalytic amount of Cu 2O (5 mol%) as catalyst and 1 atm of environmentally benign O 2 as oxidant, without the need for other additives. This method represents a simple, green, and atom-efficient synthesis of 2,5-disubstituted tetrazoles. The Royal Society of Chemistry 2012.
Hypervalent iodine in synthesis 87: The synthesis of 2,5-diaryl-2H- tetrazoles
Zhou, Tao,Chen, Zhen-Chu
, p. 404 - 405 (2007/10/03)
In the presence of cuprous iodide and potassium carbonate, N-arylation of 5-aryl-2H-tetrazole with a diaryliodonium salt proceeds smoothly in DMF at room temperature to give 2, 5-diaryl-2H-tetrazoles in moderate to good yield.
Palladium- and copper-catalyzed selective arylation of 5-aryltetrazoles by diaryliodonium salts
Beletskaya, Irina P.,Davydov, Dmitri V.,Gorovoy, Matvey S.
, p. 6221 - 6223 (2007/10/03)
Palladium(0)-catalyzed arylation of 5-aryltetrazoles in t-BuOH at 80°C with diaryliodonium salts proceeds in the presence of copper(II) phenylcyclopropyl carboxylate regioselectively at the N2 position.
