204444-02-0

Upstream product

• 96-13-9 2,3-Dibromopropan-1-ol 
• 1822-66-8 3,4-dihydroxythiophene-2,5-dicarboxylic acid diethyl ester 
• 616-23-9 2,3-Dichloro-1-propanol 
• 3132-64-7 1,2-Epoxy-3-bromopropane 

Downstream Products

• 955373-67-8 2,3-dihydrothieno[3,4-b][1,4]dioxin-2-carboxylic acid 
• 146796-02-3 (2,3-dihydrothieno[3,4-b][1,4]dioxin-3-yl)methanol 

Relevant academic research and scientific papers

2-HYDROXYMETHYL-2,3-DIHYDRO-THIENO[3,4-b][1,4]DIOXIN-5,7-DICARBOXYLIC ACID DIALKYL ESTER PRODUCTION METHOD

PROBLEM TO BE SOLVED: To provide a production method which can selectively provide 2-hydroxymethyl-2,3-dihydro-thieno[3,4-b][1,4]dioxin-5,7-dicarboxylic acid dialkyl ester with a good yield without complicated refinement. SOLUTION: A method of producing 2-hydroxymethyl-2,3-dihydro-thieno[3,4-b][1,4]dioxin-5,7-dicarboxylic acid dialkyl ester comprises reacting dihalogenated propanol with 3,4-dihydroxythiophene-2,5-dicarboxylic acid dialkyl ester in the presence of a base in a polar solvent. Based on the content of 3,4-dihydroxythiophene-2,5-dicarboxylic acid dialkyl ester represented by the specified general formula (2), the content of sodium ions is 1000 ppm or less or the content of calcium ions is 800 ppm or less, and their sum is 2500 ppm or less. The used amount of dihalogenated propanol represented by the specified general formula (3) based on that of 3,4-dihydroxythiophene-2,5-dicarboxylic acid dialkyl ester represented by the general formula (2) is from 1.3 molar equivalents to 2.1 molar equivalents inclusive. COPYRIGHT: (C)2016,JPO&INPIT

PREPARATION METHOD OF 2-HYDROXYMETHYL-2,3-DIHYDRO-THIENO[3,4-b][1,4]DIOXIN

PROBLEM TO BE SOLVED: To provide a preparation method that can produce 2-hydroxymethyl-2,3-dihydro-thieno[3,4-b][1,4]dioxin in high yield without performing complicated purification. SOLUTION: Provided is a 2-hydroxymethyl-2,3-dihydro-thieno[3,4-b][1,4]dioxin preparation method that includes: a step of hydrolysis process in which 3,4-dihydroxy-thiophene-2,5-dicarboxylic acid dialkyl ester and halogenated propanol are allowed to react in the presence of a weak base to yield 2-hydroxymethyl-2,3-dihydro-thieno[3,4-b][1,4]dioxin-5,7-dicarboxylic acid, or a mixture of dialkyl ester thereof, followed by hydrolyzing the same with a strong base to yield only dicarboxylic acid derivatives; and in succession a step of decarbonating the same in the presence of a copper catalyst to yield 2-hydroxymethyl-2,3-dihydro-thieno[3,4-b][1,4]dioxin of the formula. COPYRIGHT: (C)2015,JPOandINPIT

Prussian blue nanoparticles protected by the water-soluble π-conjugated polymer PEDOT-S: Synthesis and multiple-color pH-sensing with a redox reaction

Prussian blue nanoparticles (PB NPs), stabilized for the first time by the π-conjugated polymer poly(4-(2,3-dihydrothieno[3,4-b][1,4]dioxin-2yl-methoxy- 1-butanesulfonic acid, potassium salt) (PEDOT-S), demonstrated a novel multiple-color pH-sensing function with a redox reaction based on the electronic interaction between the PB nano-core and the PEDOT-S shell. The Royal Society of Chemistry 2009.

CARBOXYLIC ACID-MODIFIED EDOT FOR BIOCONJUGATION

An electroconductive carboxylic acid functionalized monomer corresponding to Formula (I), wherein A represents a hydrogen or a carboxyl group. Polymerized monomers of Formula (I) conjugated with a biomolecule result in conjugated PEDOT polymers of Formula (III) wherein A is a hydrogen or a carboxylic acid group and B is a biomolecule selected from the group consisting of a peptide, a protein, a lipid, a carbohydrate and a polynucleotide. The biomolecule conjugated polymers can be disposed onto an electrically conductive substrate wherein the substrate has a first layer of PEDOT polymerized on a surface of the substrate and a second layer of biomolecule conjugated PEDOT polymer of Formula (III) polymerized on the first layer of PEDOT. The first and second layers form a charge transport material in electrical communication with the conductive substrate. The electrically conductive substrate further comprises a dopant.

DERIVATIZED 3,4-ALKYLENEDIOXYTHIOPHENE MONOMERS, METHODS OF MAKING THEM, AND USE THEREOF

The present invention relates to methods of making derivatized 3,4-alkylenedioxythiophene monomers and methods of using the 3,4-alkylenedioxythiophene monomers.

Synthesis and polymerization of new monomers derived from 3,4- ethylenedioxythiophene

We report here the results of the synthesis of soluble polymers derived from 3,4-ethylenedioxythiophene. Starting from a 3,4-ethylenedioxythiophene monomer functionalized by an hydroxymethyl group, we synthesized several monomers bearing different side groups. The influence of alkyl chain length of side groups was studied in order to improve the solubility of the resulting polymer obtained by chemical oxydation. The optical properties of some chemically polymerized materials are also reported.