2045-25-2

Basic information

• Product Name: 2-AMINO-4-MORPHOLINO-S-TRIAZINE
• Synonyms: 2-AMINO-4-MORPHOLINO-S-TRIAZINE;4-(4-Morpholinyl)-1,3,5-triazin-2-amine;4-Morpholino-1,3,5-triazin-2-amine;(4-morpholino-s-triazin-2-yl)amine;4-morpholin-4-yl-1,3,5-triazin-2-amine;4-(4-morpholinyl)-1,3,5-triazin-2-amine(SALTDATA: FREE);1,3,5-Triazin-2-amine, 4-(4-morpholinyl)-;1,3,5-Triazin-2-amine, 4-(4-morpholinyl)- (9CI)
• CAS NO: 2045-25-2
• Molecular Formula: C₇H₁₁N₅O
• Molecular Weight: 181.2
• Mol File: 2045-25-2.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 434.8 °C at 760 mmHg
• Flash Point: 216.8 °C
• Appearance: /
• Density: 1.345 g/cm³
• Vapor Pressure: 9.17E-08mmHg at 25°C
• Refractive Index: 1.607
• CAS DataBase Reference: 2-AMINO-4-MORPHOLINO-S-TRIAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-4-MORPHOLINO-S-TRIAZINE(2045-25-2)
• EPA Substance Registry System: 2-AMINO-4-MORPHOLINO-S-TRIAZINE(2045-25-2)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 2045-25-2(Hazardous Substances Data)

Usage

General Description

2-AMINO-4-MORPHOLINO-S-TRIAZINE is a chemical compound with the molecular formula C5H7N7O and is known for its use as a building block in the synthesis of various organic compounds. It is a heterocyclic compound with a triazine ring containing an amino group and a morpholino group. 2-AMINO-4-MORPHOLINO-S-TRIAZINE has been studied for its potential applications in medicinal chemistry and as an intermediate in the production of pharmaceuticals and agrochemicals. Its unique structure and properties make it a valuable tool for drug discovery and development.

InChI:InChI=1/C7H11N5O/c8-6-9-5-10-7(11-6)12-1-3-13-4-2-12/h5H,1-4H2,(H2,8,9,10,11)

Upstream product

• 3731-59-7 moroxydine 
• 68-12-2 N,N-dimethyl-formamide 
• 109-94-4 formic acid ethyl ester 
• 124-41-4 sodium methylate 
• 3160-91-6 moroxydine hydrochloride 
• 77287-34-4 formamide 

Downstream Products

• 63671-31-8 4-methoxy-N-(4-morpholin-4-yl-[1,3,5]triazin-2-yl)-benzenesulfonamide 
• 63671-30-7 N-(4-morpholin-4-yl-[1,3,5]triazin-2-yl)-toluene-4-sulfonamide 
• 63671-29-4 N-(4-morpholin-4-yl-[1,3,5]triazin-2-yl)-benzenesulfonamide 
• 63671-32-9 4-chloro-N-(4-morpholin-4-yl-[1,3,5]triazin-2-yl)-benzenesulfonamide 

Relevant articles and documents

Metal free [4+1] and [5+1] annulation reactions to prepare heterocycles using DMF and its derivatives as one-carbon source

1,2,4-Triazolo[3,4-a]pyridines and related heterocycles and substituted triazines were commonly discovered scaffolds in a variety of pharmaceutical and agrochemical agents. Herein, we report a highly efficient and practical method using DMF and its derivative for the [4+1] and [5+1] annulation reactions to prepare these heterocycles. This metal free reaction takes advantages of shelf stable DMF as solvent and carbon donor, imidazole chloride as a catalyst, the mild reaction condition tolerates a broad substrate range and substitutes. The prepared 3-unsubstituted 1,2,4-triazolo[3,4-a]pyridine and derivatives allow further introduction of a variety of functional group1 at 3-position.

Regioselective synthesis of imidazo[1,2-a][1,3,5]triazines and 3,4-dihydroimidazo[1,2-a][1,3,5]triazines from [1,3,5]triazin-2,4-diamines

An efficient and practical procedure was developed to prepare novel imidazo[1,2-a][1,3,5]triazines and 3,4-dihydroimidazo[1,2-a][1,3,5]triazines with a good regioselectivity and high yields, starting from dicyandiamide and the corresponding arylamines. Mechanistic studies for the subsequent cyclocondensation with chloroacetaldehyde support a pathway, which begins with the displacement of the chloro atom activated by an adjacent CO group, followed by cyclization and dehydration.