3160-91-6

Basic information

• Product Name: Moroxydine hydrochloride
• Synonyms: virustat;1-morpholinocarbonimidoylguanidine hydrochloride;Moroxydine hydrochlorid;N-CarbaMiMidoylMorpholine-4-carboxiMidaMide hydrochloride;N-(aminoiminomethyl)-4-morpholinecarboximidamide,hydrochloride (1:1);Guanidine,N-(amino-4-morpholinylmethyl)-, hydrochloride (1:1);N-(AMINOIMINOMETHYL)-4-MORPHOLINECARBOXIMIDAMIDE HYDROCHLORIDE;MORPHOLINO-BIGUANIDE HYDROCHLORIDE
• CAS NO: 3160-91-6
• Molecular Formula: C₆H₁₃N₅O*ClH
• Molecular Weight: 207.66
• EINECS: 221-612-6
• Mol File: 3160-91-6.mol
• Article Data: 8

Chemical Properties

• Melting Point: 211-214 °C(lit.)
• Boiling Point: 327 °C at 760 mmHg
• Flash Point: 151.6 °C
• Appearance: white crystalline powder
• Vapor Pressure: 0.000207mmHg at 25°C
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: DMSO (Very Slightly, Heated), Water (Slightly)
• Merck: 14,6272
• CAS DataBase Reference: Moroxydine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: Moroxydine hydrochloride(3160-91-6)
• EPA Substance Registry System: Moroxydine hydrochloride(3160-91-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• RTECS: QD9815000
• Hazardous Substances Data: 3160-91-6(Hazardous Substances Data)

Usage

Originator

Grippe,Nissin

Uses

Different sources of media describe the Uses of 3160-91-6 differently. You can refer to the following data:
1. Moroxydine hydrochloride is an antiviral used against a number of RNA and DNA viruses.
2. Moroxydine is an antiviral used against a number of RNA and DNA viruses.

Manufacturing Process

43.5 g morpholine, 41.7 ml concentrated hydrochloric acid, 40 ml of water, and 42 g dicyandiamide are refluxed for 48 hours, whereupon the reaction mixture is cooled to +5°C and filtered. The filtrate is evaporated to dryness and extracted and extracted with boiling ethanol. Yield: 50 g. The formed 4- morpholinecarboximidoylguanidine hydrochloride is purified by recrystallization from methanol. The salt may be converted into the base by adding equivalent of any basic compound (triethylamine, sodium bicarbonate and so on).In practice it is usually used as hydrochloride.

Therapeutic Function

Antiviral

General Description

Determination of moroxydine hydrochloride in Gan Mao Qing capsules by derivative spectrophotometric signal multiplier method has been reported. Therapeutical efficiency of moroxidine hydrochloride against herpes virus induced keratoconjunctivitis has been evaluated by immunofluorescence techniques.

InChI:InChI=1/C6H13N5O.ClH/c7-5(8)10-6(9)11-1-3-12-4-2-11;/h1-4H2,(H5,7,8,9,10);1H

Upstream product

• 110-91-8 morpholine 
• 127099-85-8 N-Cyanoguanidine 
• 111-46-6 diethylene glycol 
• 10024-89-2 morpholin hydrochloride 

Downstream Products

• 29936-03-6 N-[4-ethyl-5-(2-hydroxy-phenyl)-6-phenyl-pyrimidin-2-yl]-morpholine-4-carboximidic acid amide 
• 43153-45-3 4-(4-methoxyphenyl)-6-morpholino-1,3,5-triazin-2-amine 
• 1430334-13-6 4-(4-p-tolylimidazo[1,2-a][1,3,5]triazin-2-yl)morpholine 
• 1430334-14-7 4-(4-benzylimidazo[1,2-a][1,3,5]triazin-2-yl)morpholine 
• 1430334-15-8 4-(4-(2-nitrobenzyl)imidazo[1,2-a][1,3,5]triazin-2-yl)morpholine 
• 1430334-18-1 4-(4-p-tolyl-3,4-dihydroimidazo[1,2-a][1,3,5]triazin-2-yl)morpholine 
• 1430334-19-2 4-(4-benzyl-3,4-dihydroimidazo[1,2-a][1,3,5]triazin-2-yl)morpholine 
• 1430334-20-5 4-(4-(2-nitrobenzyl)-3,4-dihydroimidazo[1,2-a][1,3,5]triazin-2-yl)morpholine 
• 43153-40-8 4-(4-methylphenyl)-6-morpholino-1,3,5-triazin-2-amine 
• 1430334-09-0 4-benzyl-6-(morpholin-4-yl)-1,3,5-triazin-2-amine 
• 1430334-10-3 4-morpholino-6-(2-nitrobenzyl)-1,3,5-triazin-2-amine 
• 2045-25-2 4-morpholino-1,3,5-triazin-2-amine 
• 35541-11-8 2-amino-4-(1’-morpholinyl)-6-phenyl-1,3,5-triazine 

Relevant articles and documents

Synthesis method and application of morpholine guanidine hydrochloride

The invention relates to the field of organic synthesis, in particular to a synthesis method of morpholine guanidine hydrochloride. The method comprises the following steps: (1) carrying out a salt formation reaction, adding morpholine into a reactor, performing stirring, dropwise adding concentrated hydrochloric acid to start the salt formation reaction, stopping the dripping addition of concentrated hydrochloric acid when the pH value is 1-2, completing the reaction, performing dewatering by vacuum concentration to obtain morpholine hydrochloride; (2) carrying out an addition reaction, adding an organic solvent S1 and dicyandiamide into morpholine hydrochloride, starting the addition reaction, performing cooling to room temperature after the reaction is completed, performing stirring andvacuum filtration, washing the filter cake with an organic solvent S2, and performing drying to obtain a morpholine guanidine hydrochloride crude product; and (3) performing refining, performing recrystallization on the morpholine guanidine hydrochloride crude product with ethanol to obtain the morpholine guanidine hydrochloride refined product. The solvent used in the method is an edible flavorwhich is allowed to be used in GB 2760, the boiling point of the solvent is the optimum reaction temperature, the reactants are all dissolved in the solvent at the temperature, the reaction is a homogeneous reaction, the reaction product is insoluble in the solvent, the crude product is obtained by the direct filtration, and the post-treatment is simple.

BIGUANIDE COMPOUND AND USE THEREOF

The present invention relates to a guanidine compound and a use thereof, and more specifically, to a guanidine derivative showing excellent effects of inhibiting cancer cell proliferation, cancer metastasis, and cancer recurrence; a preparation method thereof; and a pharmaceutical composition containing the same as an active ingredient. Compared to existing drugs, the guanidine derivative according to the present invention shows excellent effects of inhibiting cancer cell proliferation, cancer metastasis, and cancer recurrence even with small doses, and may thus be effectively used in preventing or treating various cancers such as uterine cancer, breast cancer, stomach cancer, brain cancer, rectal cancer, colorectal cancer, lung cancer, skin cancer, blood cancer, liver cancer, etc., inhibiting cancer cell proliferation and cancer metastasis.

Regioselective synthesis of imidazo[1,2-a][1,3,5]triazines and 3,4-dihydroimidazo[1,2-a][1,3,5]triazines from [1,3,5]triazin-2,4-diamines

An efficient and practical procedure was developed to prepare novel imidazo[1,2-a][1,3,5]triazines and 3,4-dihydroimidazo[1,2-a][1,3,5]triazines with a good regioselectivity and high yields, starting from dicyandiamide and the corresponding arylamines. Mechanistic studies for the subsequent cyclocondensation with chloroacetaldehyde support a pathway, which begins with the displacement of the chloro atom activated by an adjacent CO group, followed by cyclization and dehydration.