204501-99-5Relevant academic research and scientific papers
Synthesis and molecular modeling of a lisinopril-tryptophan analogue inhibitor of angiotensin I-converting enzyme
Nchinda, Aloysius T.,Chibale, Kelly,Redelinghuys, Pierre,Sturrock, Edward D.
, p. 4616 - 4619 (2006)
With a view to developing a more C-domain-selective angiotensin I-converting enzyme (ACE)-inhibitor, a novel analogue of lisinopril has been synthesized which incorporates a bulky P2′ tryptophan functionality. This inhibitor demonstr
DUAL ACE C-DOMAIN/NEP INHIBITORS
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Page/Page column 20-21, (2017/10/31)
A superior dual ACE/NEP inhibitor is a combination that selectively targets the ACE C-domain in addition to inhibiting NEP. Such a dual ACE C-domain/NEP inhibitor can be used in the treatment of diverse cardiovascular diseases, including hypertension and heart failure.
