204520-30-9

Basic information

• Product Name: (4-Methoxy-phenyl)-phenyl-(4-phenyl-phthalazin-1-yl)-methanol
• Synonyms: (4-Methoxy-phenyl)-phenyl-(4-phenyl-phthalazin-1-yl)-methanol
• CAS NO: 204520-30-9
• Molecular Weight: 418.495
• Mol File: 204520-30-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (4-Methoxy-phenyl)-phenyl-(4-phenyl-phthalazin-1-yl)-methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (4-Methoxy-phenyl)-phenyl-(4-phenyl-phthalazin-1-yl)-methanol(204520-30-9)
• EPA Substance Registry System: (4-Methoxy-phenyl)-phenyl-(4-phenyl-phthalazin-1-yl)-methanol(204520-30-9)

Safety Data

• Hazardous Substances Data: 204520-30-9(Hazardous Substances Data)

Upstream product

• 100-58-3 phenylmagnesium bromide 
• 204520-35-4 (4-Methoxy-phenyl)-(4-phenyl-phthalazin-1-yl)-methanone 

Downstream Products

• 7188-22-9 1-phenylphthalazine 
• 1023-17-2 4-methoxyphenyl benzyl ketone 
• 611-94-9 4-Methoxybenzophenone 

Relevant articles and documents

Carbon-carbon bond cleavage of α-hydroxybenzylheteroarenes catalyzed by cyanide ion: Retro-benzoin condensation affords ketones and heteroarenes and benzyl migration affords benzylheteroarenes and arenecarbaldehydes

4-(α-Benzylα-hydroxybenzyl)quinazoline (4a) underwent retro-benzoin condensation catalyzed by cyanide ion to give deoxybenzoin (2a) and quinazoline (5a). Similarly, several nitrogen-containing heteroarenes (4, 9, 12, 16-19) having an α-hydroxybenzyl group at the α-position of the nitrogen underwent retro-benzoin type condensation to afford kelones (2) and heteroarenes (5). However, similar reaction of pyrazolopyrimidines (13, 14, 15) having an α-benzyl-α-hydroxybelzyl group resulted in benzyl migration, giving benzylpyrazolopyrimidines (8) and arenecarbaldehydes (3). Tetrabutylammonium cyanide (11, Bu4NCN) was a more effective cyanide ion donor than KCN (10). The retro-benzoin condensation was applied to the synthesis of 2-substituted quinazolines (38) from 2-chloro-4- aroylquinazolines (34), using the aroyl group as a protecting and electron- withdrawing group.