204521-63-1

Basic information

• Product Name: Nε-PalMitoyl-L-glutaMic Acid γ-SucciniMidyl-α-tert-butyl Ester
• Synonyms: 1-tert-butyl 2,5-dioxopyrrolidin-1-yl (2S)-2-hexadecanaMidopentanedioate;Nε-Hexadecanoyl-L-glutaMic Acid α-t-Butyl-γ-2,5-dioxopyrrolidin-1-yl-diester;Pal-Glu(OSu)-OtBu;Nε-Palmitoyl-L-glutamic Acid;N-Palmitoyl-L-glutamic acid alpha-tert- butyl ester gamma-succinimidyl ester;N-Palmitoyl-L-glutamic acid α-tert- butyl ester γ-succinimidyl ester≥ 99% (HPLC);Palmitoyl-Glu(OSu)-OtBu;Palm-L-Glu(OSu)-OtBu
• CAS NO: 204521-63-1
• Molecular Formula: C₂₉H₅₀N₂O₇
• Molecular Weight: 538.7165
• Product Categories: Amino Acids & Derivatives;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 204521-63-1.mol
• Article Data: 8

Chemical Properties

• Melting Point: 86.0 to 90.0 °C
• Appearance: /
• Density: 1.08±0.1 g/cm3(Predicted)
• Storage Temp.: Hygroscopic, Refrigerator, Under Inert Atmosphere
• Solubility: Chloroform (Slightly), Methanol (Slightly, Heated)
• PKA: 14.40±0.46(Predicted)
• CAS DataBase Reference: Nε-PalMitoyl-L-glutaMic Acid γ-SucciniMidyl-α-tert-butyl Ester(CAS DataBase Reference)
• NIST Chemistry Reference: Nε-PalMitoyl-L-glutaMic Acid γ-SucciniMidyl-α-tert-butyl Ester(204521-63-1)
• EPA Substance Registry System: Nε-PalMitoyl-L-glutaMic Acid γ-SucciniMidyl-α-tert-butyl Ester(204521-63-1)

Safety Data

• Hazardous Substances Data: 204521-63-1(Hazardous Substances Data)

Usage

Chemical Properties

White crystalline powder

Uses

Different sources of media describe the Uses of 204521-63-1 differently. You can refer to the following data:
1. Used in the preparation of lipophilic human glucagon-like peptide-1 derivatives with protracted action profiles. An antiobesity agent.
2. Nε-PalMitoyl-L-glutaMic Acid γ-SucciniMidyl-α-tert-butyl Ester is used in the preparation of lipophilic human glucagon-like peptide-1 derivatives with protracted action profiles.

Upstream product

• 14464-31-4 palmitic acid N-succinimide ester 
• 57-10-3 1-hexadecylcarboxylic acid 
• 6066-82-6 1-hydroxy-pyrrolidine-2,5-dione 
• 536721-25-2 L-glutamic acid, N-(1-oxohexadecyl)-, 1-(1,1-dimethylethyl) ester 
• 45120-30-7 L-glutamic acid α-tert-butyl ester 
• 105832-38-0 O-(N-succinimidyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate 

Relevant articles and documents

AN IMPROVED PROCESS FOR PREPARATION OF LIRAGLUTIDE

The present invention relates to an improved process for the preparation of Liraglutide. The present invention further related an improved process for the preparation of substantially pure material having a purity of greater than or equal to 99.5% by HPLC.

Preparation method of high-purity liraglutide side chain

The invention discloses a preparation method of a high-purity liraglutide side chain, palmitic acid, N-hydroxysuccinimide and N, N'-diisopropylcarbodiimide are used as starting materials to react to obtain Palmitoyl-OSu, Palmitoyl-Glu-OtBu, Liraglutide side chain crude product Palmitoyl-Glu (OSu)-OtBu in sequence; the reaction solution is filtered, the obtained filtrate is washed with an acidic aqueous solution, and an organic phase is concentrated the until being dry; the organic phase is recrystallized by using an alkane and a fatty alcohol or a mixed solvent of the alkane and the fatty alcohol to obtain the high-purity liraglutide side chain. The method for preparing the high-purity liraglutide side chain is simple to operate, the synthesis period is short, the cost is low, the after-treatment is easy, the product purity can reach 99.41%, and the method can effectively remove HOSU, DIU, tetradecanoic acid impurities, L5-S2 and octadecanoic acid impurities and other unknown impurities, and is beneficial to large-scale production.

INSULIN DIMER-INCRETIN CONJUGATES

Insulin dimers conjugated to peptides having at least one incretin activity are disclosed.