204523-65-9Relevant academic research and scientific papers
Remarkable tethering effect on DNA cleavage of propargylic sulfone conjugates with intercalating moieties
Dai, Wei-Min,Li, Quan,Fong, Kin Chiu,Chow, Chun Wo,Zhou, Ling,Hamaguchi, Wataru,Nishimoto, Sei-Ichi
, p. 169 - 174 (1998)
A number of novel propargylic sulfone conjugates 3 and 4 with intercalating moieties were synthesized and evaluated for DNA cleavage activity through nucleic base alkylation. A remarkable enhancement in DNA cleaving potency was observed with those conjugates 3 possessing a suitable spacer, a right attachment point at the aromatic ring, and a good intercalator.
