Bioorganic and Medicinal Chemistry Letters p. 169 - 174 (1998)
Update date:2022-08-02
Topics:
Dai, Wei-Min
Li, Quan
Fong, Kin Chiu
Chow, Chun Wo
Zhou, Ling
Hamaguchi, Wataru
Nishimoto, Sei-Ichi
A number of novel propargylic sulfone conjugates 3 and 4 with intercalating moieties were synthesized and evaluated for DNA cleavage activity through nucleic base alkylation. A remarkable enhancement in DNA cleaving potency was observed with those conjugates 3 possessing a suitable spacer, a right attachment point at the aromatic ring, and a good intercalator.
View MoreJiangsu Zenji Pharmaceuticals LTD
Contact:+86-025-83172562; +1-224-888-1133(USA)
Address:No.5 Xinmofan Road
NANCHANG QINZHI SCI&TEC.CO.,LTD(expird)
Contact:+86-13687004106
Address:Hero South Road,Hero Zone,Nanchang,Jiangxi,China
website:http://www.dulynet.com/
Contact:025-84699383 -8003
Address:Room 503, Building 2, Chuangxinhui, No. 61 Wenjing Road, High-tech Development Zone, Pukou District, Nanjing City, Jiangsu Province Nanjing, Jiangsu
TIANJIN NORTH JINHENG CHEMICAL PLANT.
Contact:0086-22-59952083
Address:DongShigu Country In JiXian TianJin China
Changzhou Welton Chemical Co., Ltd,
Contact:0086-519-85910828,85920537,85912897
Address:No.8 Jinlong Road, Binjiang Park, Changzhou, Jiangsu, China.
Doi:10.1016/S0040-4020(02)00465-9
(2002)Doi:10.1021/jo00305a002
(1990)Doi:10.1007/BF02256980
(2000)Doi:10.1021/ol3009655
(2012)Doi:10.1002/chem.201702599
(2017)Doi:10.1039/C8OB02527D
(2019)
