Bioorganic and Medicinal Chemistry Letters p. 169 - 174 (1998)
Update date:2022-08-02
Topics:
Dai, Wei-Min
Li, Quan
Fong, Kin Chiu
Chow, Chun Wo
Zhou, Ling
Hamaguchi, Wataru
Nishimoto, Sei-Ichi
A number of novel propargylic sulfone conjugates 3 and 4 with intercalating moieties were synthesized and evaluated for DNA cleavage activity through nucleic base alkylation. A remarkable enhancement in DNA cleaving potency was observed with those conjugates 3 possessing a suitable spacer, a right attachment point at the aromatic ring, and a good intercalator.
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