204589-68-4

Basic information

• Product Name: Ezetimibe Related Impurity 7
• Synonyms: Ezetimibe Related Impurity 7;Ezetimibe Impurity 37
• CAS NO: 204589-68-4
• Molecular Formula: C24H19F2NO2
• Molecular Weight: 391.41
• Mol File: 204589-68-4.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 625.7±55.0 °C(Predicted)
• Appearance: /
• Density: 1.303±0.06 g/cm3(Predicted)
• Storage Temp.: Amber Vial, -20°C Freezer
• Solubility: Chloroform (Slightly, Sonicated), DMSO (Slightly), Methanol (Slightly, Sonicated
• PKA: 9.72±0.30(Predicted)
• CAS DataBase Reference: Ezetimibe Related Impurity 7(CAS DataBase Reference)
• NIST Chemistry Reference: Ezetimibe Related Impurity 7(204589-68-4)
• EPA Substance Registry System: Ezetimibe Related Impurity 7(204589-68-4)

Safety Data

• Hazardous Substances Data: 204589-68-4(Hazardous Substances Data)

Usage

Uses

3’-Anhydro Ezetimibe is a metabolite of Ezetimibe (E975000), an antihyperlipoproteinemic which is a cholesterol absorption inhibitor.

Upstream product

• 70627-52-0 4-benzyloxybenzylidene-N-(4-fluoro)phenylanisidine 
• 591-80-0 pent-4-enoic acid 
• 163222-32-0 (3R,4S)-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3(S)-hydroxypropyl]-4-(4-benzyloxyphenyl)-2-azetidinone 
• 204589-80-0 methyl 3-((2S,3R)-2-(4-(benzyloxy)phenyl)-1-(4-fluorophenyl)-4-oxoazetidin-3-yl)propanoate 
• 163222-33-1 ezetemibe 
• 352-34-1 4-fluoro-1-iodobenzene 
• 204589-84-4 3-((3R,4S)-1-(4-fluorophenyl)-2-oxo-4-(4-(benzyloxy)phenyl)azetidin-3-yl)propionic acid chloride 
• 204589-82-2 (3R,4S)-1-(4-fluorophenyl)-3-(3-hydroxy-3-oxopropyl)-4-(4-benzyloxyphenyl)-2-azetidinone 
• 219653-96-0 (Z)-1-(4-(benzyloxy)phenyl)-N-(4-fluorophenyl)methaneimine 
• 190595-65-4 (3R,4S)-4-[4-(benzyloxy)phenyl]-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]azetidin-2-one 

Relevant articles and documents

Synthesis of 3-arylpropenyl, 3-arylpropynyl and 3-arylpropyl 2-azetidinones as cholesterol absorption inhibitors: Application of the palladium-catalyzed arylation of alkenes and alkynes

A series of 3-(3'-arylpropenyl)-2-azetidinones 8a-8k and 3-(3'-arylpropynyl)-2-azetidinones 16m-16p were prepared by the palladium-catalyzed arylation of 3-(3'-propenyl)-2-azetidinone 7, or by arylation of 4-pentenoic acid, or via ethyl 4-pentynoate followed by 2-azetidinone ring construction. The unsaturated 2-azetidinones were transformed to their saturated analogs 9a-9p by catalytic hydrogenation. Azetidinones 8a-8k, 9a-9p, and 16m-16p were evaluated for their biological activity as cholesterol absorption inhibitors in hamsters. (C) 2000 Elsevier Science Ltd.