20465-01-4

Basic information

• Product Name: dimethyl butylphosphoramidate
• CAS NO: 20465-01-4
• Molecular Formula: C₆H₁₆NO₃P
• Molecular Weight: 181.1699
• Mol File: 20465-01-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 204.2°C at 760 mmHg
• Flash Point: 77.3°C
• Density: 1.045g/cm³
• Vapor Pressure: 0.266mmHg at 25°C
• Refractive Index: 1.419
• CAS DataBase Reference: dimethyl butylphosphoramidate(CAS DataBase Reference)
• NIST Chemistry Reference: dimethyl butylphosphoramidate(20465-01-4)
• EPA Substance Registry System: dimethyl butylphosphoramidate(20465-01-4)

Safety Data

• Hazardous Substances Data: 20465-01-4(Hazardous Substances Data)

Upstream product

• 32997-27-6 N-n-butyl-benzothiazolesulphenamide 
• 121-45-9 phosphorous acid trimethyl ester 
• 7332-00-5 n-butylazide 
• 109-73-9 N-butylamine 
• 868-85-9 Dimethyl phosphite 
• 813-77-4 Dimethyl chlorophosphate 

Downstream Products

• 6944-59-8 3-n-butylquinazoline-2,4-(1H,3H)-dione 

Relevant articles and documents

An efficient synthesis of phosphoramidates from halides in aqueous ethanol

An environment friendly and efficient synthesis of primary phosphoramidates has been developed from benzyl/allyl/alkyl/propargyl halides in aqueous ethanol as a green reaction medium via in-situ formation of azide. The method is simple, metal free and high yielding at room temperature with wide substrate scope and functional group compatibility. The optimized protocol can be used for synthesis of phosphoramidate intermediates used as prodrug moieties to improve therapeutic potential of the parent drug.

ON THE REACTION OF BENZOTHIAZOL-2-YL SULPHENAMIDES WITH PHOSPHITES

A study of the synthesis of phosphoramidates from phosphites and benzothiazol-2-yl-sulphenamides, indicates that a quinquecovalent phosphorane is an intermediate.Since the initial step in this reaction does not involve attack of phosphorus on nitrogen, it is unlikely that these sulphenamides will act as electrophilic aminating agents towards non-phosphorus nucleophiles.An efficient new method for preparing benzothiazol-2-yl-sulphenamides is reported.