204864-54-0Relevant academic research and scientific papers
Synthesis of a non-nucleoside reverse transcriptase inhibitor in the alkenyldiarylmethane (ADAM) series with optimized potency and therapeutic index
Cushman, Mark,Casimiro-Garcia, Agustin,Williamson, Karen,Rice, William G.
, p. 195 - 198 (1998)
A novel alkenyldiarylmethane (ADAM) analog has been synthesized with enhanced potency as an anti-HIV agent. The new compound (ADAM II) inhibits the cytopathic effect of HIV-I(RF) in CEM-SS cells with an EC50 of 13 nM, while it shows cytotoxicit
New alkenyldiarylmethanes with enhanced potencies as anti-HIV agents which act as non-nucleoside reverse transcriptase inhibitors
Cushman, Mark,Casimiro-Garcia, Agustin,Hejchman, Elzbieta,Ruell, Jeffrey A.,Huang, Mingjun,Schaeffer, Catherine A.,Williamson, Karen,Rice, William G.,Buckheit Jr., Robert W.
, p. 2076 - 2089 (2007/10/03)
Twenty-two new alkenyldiarylmethanes (ADAMs) were synthesized and evaluated for inhibition of HIV-1 replication. The most potent compound proved to be methyl 3',3'-dichloro-4',4'dimethoxy-5',5'-bis(methoxycarbonyl)- 6,6-diphenyl-5-hexenoate (ADAM II), whi
