204995-13-1Relevant academic research and scientific papers
Synthesis of 4-arylaminoquinazolines and 2-aryl-4-arylaminoquinazolines from 2-aminobenzonitrile, anilines and formic acid or benzaldehydes
Szczepankiewicz, Wojciech,Suwiński, Jerzy,Bujok, Robert
, p. 9343 - 9349 (2000)
2-Aminobenzonitrile treated with anilines in the presence of aluminium chloride gave respective 2-amino-N-arylbenzamidines. 4-Arylaminoquinazolines lacking a substituent at the 2 position were obtained directly by heating 2-amino-N-arylbenzamidines in formic acid; in similar conditions other carboxylic acids did not react with the amidines. The latter when treated with aldehydes afforded 2-aryl-4-arylimino-1H-2,3-dihydroquinazolines readily oxidizable by potassium permanganate to 2-aryl-4-arylaminoquinazolines. (C) 2000 Elsevier Science Ltd.
Synthesis of N-aryl-3H-indazol-3-imine and N-aryl-1H-indazol-3-amine via Na2WO4/H2O2 mediated by intramolecular N–N coupling
Sajadi, Mahdieh Sadat,Darehkordi, Ali,Hosseini, Seyed Mohammad Sadegh
, (2021/03/01)
A fast and convenient method for synthesis of N-aryl-1H-indazol-3-amine and N-aryl-3H-indazol-3-imine compounds has been described via intramolecular oxidative cyclization of the 2-amino-Nˊ-arylbenzimidamide intermediates by Na2WO4/H2O2 in excellent yields. This procedure has several advantages such as mild reaction conditions, short reaction time, and excellent yields, making this methodology practical.
Palladium-catalyzed synthesis of novel trifluoromethylated quinazolinone, N-arylquinazoline and N-benzylquinazoline derivatives
Sajadi, Mahdieh Sadat,Kazemi, Elham,Darehkordi, Ali
supporting information, (2021/04/23)
A simple and palladium-catalyzed procedure for synthesis of a novel series of potentially biologically active trifluoromethyl-substituted quinazolinones and N-arylquinazoline derivatives via condensation-cyclization reaction of 2-aminobenzamide, 2-amino-N′-arylbenzimidamides and 2-amino-N′-benzylbenzimidamides with trifluoroacetimidoyl chlorides has been developed. noteworthy, this investigation showed the possible of transition-metal-catalyzed activation of trifluoroacetimidoyl chlorides as a carbon trifluoromethylated source for the synthesis of quinazolines and quinazolinone derivatives in good to excellent yields.
Synthesis of (Z)-2-(4-(arylimino)-3,4-dihydroquinazolin-2(1 H)-ylidene)-1H-indene-1,3(2H)dione using 2-amino-AT-aryl-benzimidamides as a starting material
Abdel-Latif, Fathy F.,Ei-Shaieb, Kamal M.,El-Deen, Ahmed G.
scheme or table, p. 699 - 701 (2011/04/22)
The reaction between 2-amino-N'-arylbenzimidamide derivatives (3a-g) and 2-dicyanomethyleneindan-1,3-dione (4, CNIND) is described. The product that was obtained in moderate to good yields via CT-complexation is identified as (Z)-2-[4-(arylimino)-3,4-dihy
