20503-36-0

Basic information

• Product Name: SELENOPHENO[3,2-B]THIOPHENE-5-CARBOXYLIC ACID
• Synonyms: SELENOPHENO[3,2-B]THIOPHENE-5-CARBOXYLIC ACID
• CAS NO: 20503-36-0
• Molecular Formula: C7H4O2SSe
• Molecular Weight: 231.13
• Mol File: 20503-36-0.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: SELENOPHENO[3,2-B]THIOPHENE-5-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: SELENOPHENO[3,2-B]THIOPHENE-5-CARBOXYLIC ACID(20503-36-0)
• EPA Substance Registry System: SELENOPHENO[3,2-B]THIOPHENE-5-CARBOXYLIC ACID(20503-36-0)

Safety Data

• Hazardous Substances Data: 20503-36-0(Hazardous Substances Data)

Upstream product

• 77151-57-6 ethyl 2-(thiophen-3-ylselanyl)acetate 
• 1265626-49-0 selenolo[3,2-b]thiophene-5-carboxylic acid ethyl ester 
• 1265626-48-9 ethyl 2-(2-formylthiophen-3-ylselanyl)acetate 
• 20503-37-1 selenopheno[3,2-b]thiophene 
• 124-38-9 carbon dioxide 

Relevant articles and documents

CONDENCED HETEROCYCLES 38. BROMINATION AND FORMYLATION OF ISOMERIC SELENOPHENOTHIOPHENES

-

Synthesis and anticancer activity of benzoselenophene and heteroaromatic derivatives of 1,2,9,9a-tetrahydrocyclopropa[c]benzo[e]indol-4-one (CBI)

The current study reports the synthesis of different derivatives of benzoselenophene analogs as well as a diverse series of compounds (14a-p, 15 and 16) from 1,2,9,9a-tetrahydrocyclopropa[c]benzo[e]indol-4-one (CBI) and benzoselenophene or heteroaromatic acids. The overall yield of scaffold 12 was improved by an one-pot reaction, which helps in large-scale synthesis of CBI, a duocarmycin alkylation subunit analog. The series of compounds were evaluated for their cytotoxicity against SK-OV3 ovarian cancer cell lines, which revealed that benzoselenophene can enhance or maintain the anticancer activity of the duocarmycin analog upon replacing the indole moiety. CBI-benzoselenophenes with N-amido substituents at the C-5 position, 14g, 14f and 16 (IC50 = 0.5, 1.2 and 1.6 nM, respectively), were found to be more potent than the CBI-TMI and other benzoselenophene analogs. The CBI-benzoselenophene analogs, 14f and 14g (containing N-acetamido and N-butyramido substituents, respectively), were found to be 8 and 120 times more potent than the corresponding indole analogs of CBI, 14q and 14r, respectively.

SELENOPHENE-FUSED AROMATIC COMPOUND AND MANUFACTURING METHOD THEREOF

The present disclosure relates to a method for more easily and economically producing a selenophene-fused aromatic compound derivative containing various substituents and the selenophene-fused aromatic compound produced according to the method, and the selenophenefused aromatic compound can be used for various purposes such as an intermediate of an anti-bacterial or anticancer substance, an indicator of which color is changed depending on a solvent, or a fluorescent substance.