20503-36-0Relevant academic research and scientific papers
Mixed selenium-sulfur fused ring systems as building blocks for novel polymers used in field effect transistors
Mishra, Sarada P.,Javier, Anna E.,Zhang, Rui,Liu, Junying,Belot, John A.,Osaka, Itaru,McCullough, Richard D.
, p. 1551 - 1561 (2011)
Eight novel polymer materials for transistor applications were prepared based on the fused ring building block selenolo[3,2-b]thiophene. The molecular structure of selenolo[3,2-b]thiophene was determined by single-crystal X-ray diffraction and was further modified for use as a monomer during the Stille synthesis of various copolymers containing substituted and unsubstituted thiophenes, thiazoles, dithienopyrroles (DTP) and benzothiadiazole subunits. The resultant polymers were analyzed for UV-Vis absorption and show a significant red shift when compared to regioregular poly(3-hexylthiophenes) (P3HT), attributed to the increased planarity and conjugation of the polymer backbone. Cyclic voltammetry experiments on the new polymers show that almost all of the new structures have a higher oxidation potential compared to P3HT, making them more stable toward oxidative doping under ambient atmospheres. The polymers were also evaluated for their electrical properties through their performance as the active layer in field effect transistors. The polymers showed relatively high mobility values, of which the highest observed value is 0.11 cm2 V-1 s-1, with on/off ratios of about 105.
Synthesis and anticancer activity of benzoselenophene and heteroaromatic derivatives of 1,2,9,9a-tetrahydrocyclopropa[c]benzo[e]indol-4-one (CBI)
Mhetre, Amol B.,Lee, Hangeun,Yang, Heekyoung,Lee, Kyoungmin,Nam, Do-Hyun,Lim, Dongyeol
supporting information, p. 1198 - 1208 (2017/02/10)
The current study reports the synthesis of different derivatives of benzoselenophene analogs as well as a diverse series of compounds (14a-p, 15 and 16) from 1,2,9,9a-tetrahydrocyclopropa[c]benzo[e]indol-4-one (CBI) and benzoselenophene or heteroaromatic acids. The overall yield of scaffold 12 was improved by an one-pot reaction, which helps in large-scale synthesis of CBI, a duocarmycin alkylation subunit analog. The series of compounds were evaluated for their cytotoxicity against SK-OV3 ovarian cancer cell lines, which revealed that benzoselenophene can enhance or maintain the anticancer activity of the duocarmycin analog upon replacing the indole moiety. CBI-benzoselenophenes with N-amido substituents at the C-5 position, 14g, 14f and 16 (IC50 = 0.5, 1.2 and 1.6 nM, respectively), were found to be more potent than the CBI-TMI and other benzoselenophene analogs. The CBI-benzoselenophene analogs, 14f and 14g (containing N-acetamido and N-butyramido substituents, respectively), were found to be 8 and 120 times more potent than the corresponding indole analogs of CBI, 14q and 14r, respectively.
SELENOPHENE-FUSED AROMATIC COMPOUND AND MANUFACTURING METHOD THEREOF
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Paragraph 0330; 0331, (2014/08/07)
The present disclosure relates to a method for more easily and economically producing a selenophene-fused aromatic compound derivative containing various substituents and the selenophene-fused aromatic compound produced according to the method, and the selenophene-fused aromatic compound can be used for various purposes such as an intermediate of an anti-bacterial or anticancer substance, an indicator of which color is changed depending on a solvent, or a fluorescent substance.
SELENOPHENE-FUSED AROMATIC COMPOUND AND MANUFACTURING METHOD THEREOF
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Paragraph 0126, (2014/08/19)
The present disclosure relates to a method for more easily and economically producing a selenophene-fused aromatic compound derivative containing various substituents and the selenophene-fused aromatic compound produced according to the method, and the selenophenefused aromatic compound can be used for various purposes such as an intermediate of an anti-bacterial or anticancer substance, an indicator of which color is changed depending on a solvent, or a fluorescent substance.
